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Annual Review of Virology

Volume 4, 2017

Engineered Expression of Broadly Neutralizing Antibodies Against Human Immunodeficiency Virus

Abstract

This review discusses recent progress made in developing a vaccine and novel treatments for human immunodeficiency virus (HIV). It highlights the shortcomings of the RV144 vaccination trial [ALVAC-HIV (vCP1521) and AIDSVAX B/E] and the current standard of care and proposes that engineered expression of broadly neutralizing antibodies (bNAbs) against HIV-1 could overcome these shortcomings. Current developments in three major lines of research on HIV prevention and treatment using bNAbs are reviewed: firstly, the use of sequential immunogens to activate B cells to express bNAbs; secondly, the delivery of novel and extremely potent bNAbs through passive administration; and finally, the use of gene transfer using adeno-associated viral vectors to deliver bNAbs.

Keyword(s): active immunization, adeno-associated virus, broadly neutralizing antibodies, gene transfer, HIV vaccine
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2017-09-29
2024-04-19
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Engineered Expression of Broadly Neutralizing Antibodies Against Human Immunodeficiency Virus
Annual Review of Virology 4, 491 (2017); https://doi.org/10.1146/annurev-virology-101416-041929
/content/journals/10.1146/annurev-virology-101416-041929
/content/journals/10.1146/annurev-virology-101416-041929
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