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Annual Review of Biochemistry

Volume 84, 2015

Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and Epigenetics

Abstract

Protein ADP-ribosylation is an ancient posttranslational modification with high biochemical complexity. It alters the function of modified proteins or provides a scaffold for the recruitment of other proteins and thus regulates several cellular processes. ADP-ribosylation is governed by ADP-ribosyltransferases and a subclass of sirtuins (writers), is sensed by proteins that contain binding modules (readers) that recognize specific parts of the ADP-ribosyl posttranslational modification, and is removed by ADP-ribosylhydrolases (erasers). The large amount of experimental data generated and technical progress made in the last decade have significantly advanced our knowledge of the function of ADP-ribosylation at the molecular level. This review summarizes the current knowledge of nuclear ADP-ribosylation reactions and their role in chromatin plasticity, cell differentiation, and epigenetics and discusses current progress and future perspectives.

Keyword(s): ADP-ribosylation, ARTD, chromatin, histone, NAD, PAR, PARP
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/content/journals/10.1146/annurev-biochem-060614-034506
2015-06-02
2024-04-20
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/content/journals/10.1146/annurev-biochem-060614-034506
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Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and Epigenetics
Annual Review of Biochemistry 84, 227 (2015); https://doi.org/10.1146/annurev-biochem-060614-034506
/content/journals/10.1146/annurev-biochem-060614-034506
/content/journals/10.1146/annurev-biochem-060614-034506
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