1932

Abstract

The fifth edition of the includes a new class of obsessive-compulsive and related disorders (OCRDs) that includes obsessive-compulsive disorder (OCD) and a handful of other putatively related conditions. Although this new category promises to raise awareness of underrecognized and understudied problems, its empirical validity and practical utility are questionable. This article reviews the phenomenology of OCD and then presents a critical analysis of the arguments underlying the new OCRD class. This analysis leads to a rejection of the OCRD classification on both scientific and logical grounds. The article closes with a discussion of the treatment implications of the OCRDs approach.

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2015-03-28
2024-04-24
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Literature Cited

  1. Abramowitz JS, Deacon BJ, Olatunji BO, Wheaton MG, Berman NC. et al. 2010. Assessment of obsessive-compulsive symptom dimensions: development and evaluation of the Dimensional Obsessive-Compulsive Scale. Psychol. Assess. 22:1180–98 [Google Scholar]
  2. Abramowitz JS, Deacon BJ, Whiteside SPH. 2012. Exposure Therapy for Anxiety: Principles and Practice New York: Guilford
  3. Abramowitz JS, Franklin ME, Schwartz SA, Furr JM. 2003. Symptom presentation and outcome of cognitive-behavioral therapy for obsessive-compulsive disorder. J. Consult. Clin. Psychol. 71:61049–57 [Google Scholar]
  4. Abramowitz JS, Taylor S, McKay D. 2009. Obsessive-compulsive disorder. Lancet 374:9688491–99 [Google Scholar]
  5. Abramowitz JS, Wheaton MG, Storch EA. 2008. The status of hoarding as a symptom of obsessive-compulsive disorder. Behav. Res. Ther. 46:91026–33 [Google Scholar]
  6. Am. Psychiatr. Assoc 2013. Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: Am. Psychiatr. Publ, 5th ed..
  7. Anholt GE, Aderka IM, van Balkom AJLM, Smit JH, Schruers K. et al. 2014. Age of onset in obsessive-compulsive disorder: admixture analysis with a large sample. Psychol. Med. 44:1185–94 [Google Scholar]
  8. Antony MM, Downie F, Swinson RP. 1998. Diagnostic issues and epidemiology in obsessive-compulsive disorder. Obsessive-Compulsive Disorder: Theory, Research, and Treatment RP Swinson, MM Antony, S Rachman, MA Richter 3–32 New York: Guilford [Google Scholar]
  9. Arbabi M, Farnia V, Balighi K, Mohammadi MR, Nejati-Safa AA. et al. 2008. Efficacy of citalopram in treatment of pathological skin picking, a randomized double blind placebo controlled trial. Acta Med. Iran. 46:5367–72 [Google Scholar]
  10. Arnold LM, Auchenbach MB, McElroy SL. 2001. Psychogenic excoriation: clinical features, proposed diagnostic criteria, epidemiology and approaches to treatment. CNS Drugs 15:5351–59 [Google Scholar]
  11. Azrin NH, Nunn RG. 1973. Habit-reversal: a method of eliminating nervous habits and tics. Behav. Res. Ther. 11:4619–28 [Google Scholar]
  12. Barlow DH. 2004. Anxiety and Its Disorders: The Nature and Treatment of Anxiety and Panic New York: Guilford
  13. Barr LC, Goodman WK, Price LH. 1993. The serotonin hypothesis of obsessive compulsive disorder. Int. Clin. Psychopharmacol. 8:Suppl. 279–82 [Google Scholar]
  14. Bennett CM, Miller MB, Wolford GL. 2009. Neural correlates of interspecies perspective taking in the post-mortem Atlantic Salmon: an argument for multiple comparisons correction. NeuroImage 47:Suppl. 1S125 [Google Scholar]
  15. Bienvenu OJ, Samuels JF, Riddle MA, Hoehn-Saric R, Liang KY. et al. 2000. The relationship of obsessive-compulsive disorder to possible spectrum disorders: results from a family study. Biol. Psychiatry 48:4287–93 [Google Scholar]
  16. Bjornsson AS, Didie ER, Grant JE, Menard W, Stalker E, Phillips KA. 2013. Age at onset and clinical correlates in body dysmorphic disorder. Compr. Psychiatry 54:7893–903 [Google Scholar]
  17. Bloch MH, Bartley CA, Zipperer L, Jakubovski E, Landeros-Weisenberger A. et al. 2014. Meta-analysis: hoarding symptoms associated with poor treatment outcome in obsessive-compulsive disorder. Mol. Psychiatry 19:91025–30 [Google Scholar]
  18. Bloch MH, Landeros-Weisenberger A, Dombrowski P, Kelmendi B, Wegner R. et al. 2007. Systematic review: pharmacological and behavioral treatment for trichotillomania. Biol. Psychiatry 62:8839–46 [Google Scholar]
  19. Buchanan BG, Rossell SL, Maller JJ, Toh WL, Brennan S, Castle DJ. 2013. Brain connectivity in body dysmorphic disorder compared with controls: a diffusion tensor imaging study. Psychol. Med. 43:122513–21 [Google Scholar]
  20. Chamberlain SR, Menzies LA, Fineberg NA, Del Campo N, Suckling J. et al. 2008. Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study. Br. J. Psychiatry 193:3216–21 [Google Scholar]
  21. Christenson GA, Ristvedt SL, Mackenzie TB. 1993. Identification of trichotillomania cue profiles. Behav. Res. Ther. 31:3315–20 [Google Scholar]
  22. Coles ME, Frost RO, Heimberg RG, Steketee GS. 2003. Hoarding behaviors in a large college sample. Behav. Res. Ther. 41:2179–94 [Google Scholar]
  23. Coles ME, Schofield CA, Pietrefesa AS. 2006. Behavioral inhibition and obsessive-compulsive disorder. J. Anxiety Disord. 20:81118–32 [Google Scholar]
  24. Deacon BJ, Abramowitz JS. 2005. The Yale-Brown Obsessive Compulsive Scale: factor analysis, construct validity, and suggestions for refinement. J. Anxiety Disord. 19:5573–85 [Google Scholar]
  25. Denys D, Fineberg N, Carey PC, Stein DJ. 2008. Reply. Biol. Psychiatry 63:1e7 [Google Scholar]
  26. Denys D, van der Wee N, Janssen J, De Geus F, Westenberg HGM. 2004. Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder. Biol. Psychiatry 55:101041–45 [Google Scholar]
  27. Denys D, Van Nieuwerburgh F, Deforce D, Westenberg H. 2006. Association between the dopamine D2 receptor TaqI A2 allele and low activity COMT allele with obsessive-compulsive disorder in males. Eur. Neuropsychopharmacol. 16:6446–50 [Google Scholar]
  28. Eddy KT, Dutra L, Bradley R, Westen D. 2004. A multidimensional meta-analysis of psychotherapy and pharmacotherapy for obsessive-compulsive disorder. Clin. Psychol. Rev. 24:81011–30 [Google Scholar]
  29. Fineberg NA, Saxena S, Zohar J, Craig KJ. 2011. Obsessive-compulsive disorder: boundary issues. Obsessive-Compulsive Spectrum Disorders: Refining the Research Agenda for DSM-V E Hollander, J Zohar, PJ Sirovatka, DA Regier 1–32 Washington, DC: Am. Psychiatr. Assoc. [Google Scholar]
  30. Flessner CA, Lochner C, Stein DJ, Woods DW, Franklin ME, Keuthen NJ. 2010. Age of onset of trichotillomania symptoms: investigating clinical correlates. J. Nerv. Ment. Dis. 198:12896–900 [Google Scholar]
  31. Foa EB, Kozak MJ, Goodman WK, Hollander E, Jenike MA, Rasmussen SA. 1995. DSM-IV field trial: obsessive-compulsive disorder. Am. J. Psychiatry 152:190–96 [Google Scholar]
  32. Fournier JC, DeRubeis RJ, Hollon SD, Dimidjian S, Amsterdam JD. et al. 2010. Antidepressant drug effects and depression severity: a patient-level meta-analysis. J. Am. Med. Assoc. 303:147–53 [Google Scholar]
  33. Frankenburg FR. 1984. Hoarding in anorexia nervosa. Br. J. Med. Psychol. 57:157–60 [Google Scholar]
  34. Frost RO, Tolin DF. 2008. Compulsive hoarding. Clinical Handbook of Obsessive-Compulsive Disorder and Related Problems JS Abramowitz, D McKay, S Taylor 76–94 Baltimore, MD: Johns Hopkins Univ. Press [Google Scholar]
  35. Grant JE, Odlaug BL, Chamberlain SR, Keuthen NJ, Lochner C, Stein DJ. 2012. Skin picking disorder. Am. J. Psychiatry 169:111143–49 [Google Scholar]
  36. Grant JE, Odlaug BL, Hampshire A, Schreiber LRN, Chamberlain SR. 2013. White matter abnormalities in skin picking disorder: a diffusion tensor imaging study. Neuropsychopharmacology 38:5763–69 [Google Scholar]
  37. Grant JE, Potenza MN. 2004. Impulse control disorders: clinical characteristics and pharmacological management. Ann. Clin. Psychiatry 16:127–34 [Google Scholar]
  38. Greist JH, Jefferson JW, Kobak KA, Katzelnick DJ, Serlin RC. 1995. Efficacy and tolerability of serotonin transport inhibitors in obsessive-compulsive disorder: a meta-analysis. Arch. Gen. Psychiatry 52:153–60 [Google Scholar]
  39. Grisham JR, Frost RO, Steketee G, Kim H-J, Hood S. 2006. Age of onset of compulsive hoarding. J. Anxiety Disord. 20:5675–86 [Google Scholar]
  40. Hedges DW, Brown BL, Shwalb DA, Godfrey K, Larcher AM. 2007. The efficacy of selective serotonin reuptake inhibitors in adult social anxiety disorder: a meta-analysis of double-blind, placebo-controlled trials. J. Psychopharmacol. 21:1102–11 [Google Scholar]
  41. Hollander E, Evers M. 2004. Review of obsessive-compulsive spectrum disorders: What do we know? Where are we going?. Clin. Neuropsychiatry 1:132–51 [Google Scholar]
  42. Hollander E, Friedberg JP, Wasserman S, Yeh C-C, Iyengar R. 2005. The case for the OCD spectrum. Concepts and Controversies in Obsessive-Compulsive Disorder JS Abramowitz, AC Houts 95–118 New York: Springer [Google Scholar]
  43. Hollander E, Kim S, Khanna S, Pallanti S. 2007. Obsessive-compulsive disorder and obsessive-compulsive spectrum disorders: diagnostic and dimensional issues. CNS Spectr. 12:2 Suppl. 35–13 [Google Scholar]
  44. Hollander E, Kwon JH, Stein DJ, Broatch J. 1996. Obsessive-compulsive and spectrum disorders: overview and quality of life issues. J. Clin. Psychiatry 57:3–6 [Google Scholar]
  45. Hyman SE. 2007. Can neuroscience be integrated into the DSM-V?. Nat. Rev. Neurosci. 8:9725–32 [Google Scholar]
  46. Insel TR. 2009. Translating scientific opportunity into public health impact: a strategic plan for research on mental illness. Arch. Gen. Psychiatry 66:2128–33 [Google Scholar]
  47. Insel TR, Mueller EA, Alterman I, Linnoila M, Murphy DL. 1985. Obsessive-compulsive disorder and serotonin: Is there a connection?. Biol. Psychiatry 20:111174–88 [Google Scholar]
  48. Ipser JC, Sander C, Stein DJ. 2009. Pharmacotherapy and psychotherapy for body dysmorphic disorder. Cochrane Database Syst. Rev. 2009:CD005332 [Google Scholar]
  49. Jaisoorya TS, Janardhan Reddy YC, Srinath S. 2003. The relationship of obsessive-compulsive disorder to putative spectrum disorders: results from an Indian study. Compr. Psychiatry 44:4317–23 [Google Scholar]
  50. Jenike MA, Breiter HC, Baer L, Kennedy DN, Savage CR. et al. 1996. Cerebral structural abnormalities in obsessive-compulsive disorder: a quantitative morphometric magnetic resonance imaging study. Arch. Gen. Psychiatry 53:7625–32 [Google Scholar]
  51. Keuthen NJ, Deckersbach T, Wilhelm S, Hale E, Fraim C. et al. 2000. Repetitive skin-picking in a student population and comparison with a sample of self-injurious skin-pickers. Psychosomatics 41:3210–15 [Google Scholar]
  52. Kirsch I. 2011. The Emperor's New Drugs: Exploding the Antidepressant Myth New York: Basic Books
  53. Koo M-S, Kim E-J, Roh D, Kim C-H. 2010. Role of dopamine in the pathophysiology and treatment of obsessive-compulsive disorder. Expert Rev. Neurother. 10:2275–90 [Google Scholar]
  54. Koran LM, Hanna GL, Hollander E, Nestadt G, Simpson HB. (Am. Psychiatr. Assoc.) 2007. Practice guideline for the treatment of patients with obsessive-compulsive disorder. Am. J. Psychiatry 164:7 Suppl.5–53 [Google Scholar]
  55. Kramer MD, Polusny MA, Arbisi PA, Krueger RF. 2014. Comorbidity of PTSD and SUDs: toward an etiologic understanding. Trauma and Substance Abuse: Causes, Consequences, and Treatment of Comorbid Disorders P Ouimette, JP Read 53–75 Washington, DC: Am. Psychol. Assoc, 2nd ed.. [Google Scholar]
  56. Lee H-J, Kwon S-M. 2003. Two different types of obsession: autogenous obsessions and reactive obsessions. Behav. Res. Ther. 41:111–29 [Google Scholar]
  57. Lee H-J, Kwon S-M, Kwon JS, Telch MJ. 2005. Testing the autogenous-reactive model of obsessions. Depress. Anxiety 21:3118–29 [Google Scholar]
  58. Lee H-J, Telch MJ. 2010. Differences in latent inhibition as a function of the autogenous-reactive OCD subtype. Behav. Res. Ther. 48:7571–79 [Google Scholar]
  59. Lochner C, Simeon D, Niehaus DJH, Stein DJ. 2002. Trichotillomania and skin-picking: a phenomenological comparison. Depress. Anxiety 15:283–86 [Google Scholar]
  60. Lochner C, Stein DJ. 2006. Does work on obsessive-compulsive spectrum disorders contribute to understanding the heterogeneity of obsessive-compulsive disorder?. Prog. Neuropsychopharmacol. Biol. Psychiatry 30:3353–61 [Google Scholar]
  61. Lovato L, Ferrão YA, Stein DJ, Shavitt RG, Fontenelle LF. et al. 2012. Skin picking and trichotillomania in adults with obsessive-compulsive disorder. Compr. Psychiatry 53:5562–68 [Google Scholar]
  62. Luchins DJ, Goldman MB, Lieb M, Hanrahan P. 1992. Repetitive behaviors in chronically institutionalized schizophrenic patients. Schizophr. Res. 8:2119–23 [Google Scholar]
  63. Mataix-Cols D, Pertusa A, Leckman JF. 2007. Issues for DSM-V: How should obsessive-compulsive and related disorders be classified?. Am. J. Psychiatry 164:91313–14 [Google Scholar]
  64. Mataix-Cols D, Pertusa A, Snowdon J. 2011. Neuropsychological and neural correlates of hoarding: a practice-friendly review. J. Clin. Psychol. 67:5467–76 [Google Scholar]
  65. McKay D, Abramowitz JS, Calamari JE, Kyrios M, Radomsky A. et al. 2004. A critical evaluation of obsessive-compulsive disorder subtypes: symptoms versus mechanisms. Clin. Psychol. Rev. 24:3283–313 [Google Scholar]
  66. Miller GA, Keller J. 2000. Psychology and neuroscience making peace. Curr. Dir. Psychol. Sci. 9:6212–15 [Google Scholar]
  67. Nestadt G, Samuels J, Riddle MA, Liang KY, Bienvenu OJ. et al. 2001. The relationship between obsessive-compulsive disorder and anxiety and affective disorders: results from the Johns Hopkins OCD Family Study. Psychol. Med. 31:3481–87 [Google Scholar]
  68. Neziroglu F, Rabinowitz D, Breytman A, Jacofsky M. 2008. Skin picking phenomenology and severity comparison. Prim. Care Companion J. Clin. Psychiatry 10:4306–12 [Google Scholar]
  69. NICE (Natl. Inst. Health Care Excell.) 2005. Obsessive-Compulsive Disorder: Core Interventions in the Treatment of Obsessive-Compulsive Disorder and Body Dysmorphic Disorder Manchester, UK: NICE http://nice.org.uk/guidance/cg31
  70. O'Sullivan RL, Rauch SL, Breiter HC, Grachev ID, Baer L. et al. 1997. Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging. Biol. Psychiatry 42:139–45 [Google Scholar]
  71. Odlaug BL, Grant JE. 2012. Pathological skin picking. Trichotillomania, Skin Picking, and Other Body-Focused Repetitive Behaviors JE Grant, DJ Stein, DW Woods, NJ Keuthen 21–41 Arlington, VA: Am. Psychiatr. Publ. [Google Scholar]
  72. Phillips KA, Albertini RS, Rasmussen SA. 2002. A randomized placebo-controlled trial of fluoxetine in body dysmorphic disorder. Arch. Gen. Psychiatry 59:4381–88 [Google Scholar]
  73. Phillips KA, Wilhelm S, Koran LM, Didie ER, Fallon BA. et al. 2010. Body dysmorphic disorder: some key issues for DSM-V. Depress. Anxiety 27:6573–91 [Google Scholar]
  74. Piacentini JC, Chang SW. 2006. Behavioral treatments for tic suppression: habit reversal training. Adv. Neurol. 99:227–33 [Google Scholar]
  75. Rachman S, de Silva P, Roper G. 1976. The spontaneous decay of compulsive urges. Behav. Res. Ther. 14:6445–53 [Google Scholar]
  76. Rachman S, Elliott CM, Shafran R, Radomsky AS. 2009. Separating hoarding from OCD. Behav. Res. Ther. 47:6520–22 [Google Scholar]
  77. Rachman S, Hodgson RJ. 1980. Obsessions and Compulsions Englewood Cliffs, NJ: Prentice-Hall
  78. Romanelli RJ, Wu FM, Gamba R, Mojtabai R, Segal JB. 2014. Behavioral therapy and serotonin reuptake inhibitor pharmacotherapy in the treatment of obsessive-compulsive disorder: a systematic review and meta-analysis of head-to-head randomized controlled trials. Depress. Anxiety 31:8641–52 [Google Scholar]
  79. Rosenbaum JF, Biederman J, Bolduc-Murphy EA, Faraone SV, Chaloff J. et al. 1993. Behavioral inhibition in childhood: a risk factor for anxiety disorders. Harv. Rev. Psychiatry 1:12–16 [Google Scholar]
  80. Roskies AL. 2007. Are neuroimages like photographs of the brain?. Philos. Sci. 74:5860–72 [Google Scholar]
  81. Schatzberg AF, Nemeroff CB. 2013. Essentials of Clinical Psychopharmacology Arlington, VA: Am. Psychiatr. Publ.
  82. Schreiber L, Odlaug BL, Grant JE. 2011. Impulse control disorders: updated review of clinical characteristics and pharmacological management. Front. Psychiatry 2:1 [Google Scholar]
  83. Simeon D, Stein DJ, Gross S, Islam N, Schmeidler J, Hollander E. 1997. A double-blind trial of fluoxetine in pathologic skin picking. J. Clin. Psychiatry 58:8341–47 [Google Scholar]
  84. Snorrason I, Smári J, Olafsson RP. 2010. Emotion regulation in pathological skin picking: findings from a non-treatment seeking sample. J. Behav. Ther. Exp. Psychiatry 41:3238–45 [Google Scholar]
  85. Stanley MA, Swann AC, Bowers TC, Davis ML, Taylor DJ. 1992. A comparison of clinical features in trichotillomania and obsessive-compulsive disorder. Behav. Res. Ther. 30:139–44 [Google Scholar]
  86. Stein DJ, Lochner C. 2006. Obsessive-compulsive spectrum disorders: a multidimensional approach. Psychiatr. Clin. North Am. 29:2343–51 [Google Scholar]
  87. Stein DJ, Simeon D, Cohen LJ, Hollander E. 1995. Trichotillomania and obsessive-compulsive disorder. J. Clin. Psychiatry 56:Suppl. 428–34 [Google Scholar]
  88. Summerfeldt LJ, Hood K, Antony MM, Richter MA, Swinson RP. 2004. Impulsivity in obsessive-compulsive disorder: comparisons with other anxiety disorders and within tic-related subgroups. Personal. Individ. Differ. 36:3539–53 [Google Scholar]
  89. Valenstein E. 2002. Blaming the Brain: The Truth About Drugs and Mental Health New York: Simon & Schuster
  90. Veale D, Riley S. 2001. Mirror, mirror on the wall, who is the ugliest of them all? The psychopathology of mirror gazing in body dysmorphic disorder. Behav. Res. Ther. 39:121381–93 [Google Scholar]
  91. Vul E, Harris C, Winkielman P, Pashler H. 2009. Puzzlingly high correlations in fMRI studies of emotion, personality, and social cognition. Perspect. Psychol. Sci. 4:3274–90 [Google Scholar]
  92. Wheaton MG, Abramowitz JS, Fabricant LE, Berman NC, Franklin JC. 2011. Is hoarding a symptom of obsessive-compulsive disorder?. Int. J. Cogn. Ther. 4:3225–38 [Google Scholar]
  93. Wheaton MG, Timpano KR, LaSalle-Ricci VH, Murphy D. 2008. Characterizing the hoarding phenotype in individuals with OCD: associations with comorbidity, severity and gender. J. Anxiety Disord. 22:2243–52 [Google Scholar]
  94. Whitaker R. 2011. Anatomy of an Epidemic: Magic Bullets, Psychiatric Drugs, and the Astonishing Rise of Mental Illness in America New York: Broadway Books
  95. Whiteside SP, Port JD, Abramowitz JS. 2004. A meta-analysis of functional neuroimaging in obsessive-compulsive disorder. Psychiatry Res. Neuroimaging 132:169–79 [Google Scholar]
  96. Wilhelm S, Keuthen NJ, Deckersbach T, Engelhard IM, Forker AE. et al. 1999. Self-injurious skin picking: clinical characteristics and comorbidity. J. Clin. Psychiatry 60:7454–59 [Google Scholar]
  97. Williams J, Hadjistavropoulos T, Sharpe D. 2006. A meta-analysis of psychological and pharmacological treatments for body dysmorphic disorder. Behav. Res. Ther. 44:199–111 [Google Scholar]
  98. Windheim K, Veale D, Anson M. 2011. Mirror gazing in body dysmorphic disorder and healthy controls: effects of duration of gazing. Behav. Res. Ther. 49:9555–64 [Google Scholar]
  99. Zohar J, Kennedy JL, Hollander E, Koran LM. 2004. Serotonin-1D hypothesis of obsessive-compulsive disorder: an update. J. Clin. Psychiatry 65:Suppl. 1418–21 [Google Scholar]
  100. Zurowski B, Kordon A, Wahl K, Hohagen F. 2008. Non-selective effects of selective serotonin reuptake inhibitors. Biol. Psychiatry 63:1e5 [Google Scholar]
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