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High performance surface plasmon resonance-based photonic crystal fiber biosensor for cancer cells detection

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Abstract

In order to detect cancer early and reduce fatality, a novel highly sensitive surface plasmon resonance-based photonic crystal fiber sensor with gold nanowires is suggested for six different cancer cells detection. Double gold nanowires are used as plasmonic materials where their sizes and also the geometrical parameters of the fiber are examined to obtain the best performance of the proposed sensor. The sensor response based on the refractive index variations upon cancerous cells detection is analyzed using the full-vectorial finite element method. Also, a comparative study of the single and double gold nanowires-based biosensor is done which shows noticeable performance enhancement by employing double gold nanowires. Our results show that the presented structure has high performance responses for almost six types of cancers. It displays the highest spectral and amplitude sensitivities as 53,571 nm/RIU and 2582 RIU−1 for MCF-7 and PC12 cells, respectively. Great sensitivity and resolution together with suitable figure of merit and low loss values introduce the suggested biosensor as an appropriate sensing platform for early and precise detection of cancer cells.

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Acknowledgements

This research is supported by a research grant of the University of Tabriz (number 1608). Also, the first author B. Meshginqalam would like to acknowledge the Computational Nanoelectronic Research Group (Cone) at the Faculty of Electrical Engineering, Universiti Teknologi Malaysia, for their support and contribution to this study under visiting research program. Moreover, we would like to thank Sahar Meshginghalam for language editing the paper.

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Authors and Affiliations

  1. Faculty of Physics, University of Tabriz, Tabriz, Iran

    Bahar Meshginqalam & Jamal Barvestani

Authors
  1. Bahar Meshginqalam
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  2. Jamal Barvestani
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Correspondence to Bahar Meshginqalam.

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The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Data Availability Statement

The data generated and/or analyzed during the current study are not publicly available for legal/ethical reasons but are available from the corresponding author on reasonable request.

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Meshginqalam, B., Barvestani, J. High performance surface plasmon resonance-based photonic crystal fiber biosensor for cancer cells detection. Eur. Phys. J. Plus 137, 417 (2022). https://doi.org/10.1140/epjp/s13360-022-02618-6

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  • DOI: https://doi.org/10.1140/epjp/s13360-022-02618-6

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