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Effect of Methyltriclosan on the Functioning of Isolated Rat Liver Mitochondria and Permeability of Liposomal Membranes

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Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology Aims and scope

Abstract

Effects of methyltriclosan, a biodegradation product of the antimicrobial agent triclosan, on the functional parameters of rat liver mitochondria were studied. It was found that methyltriclosan inhibits the activity of complexes II and IV of the respiratory chain. This causes a decrease in the rate of oxygen consumption by mitochondria in states 3 and 3UDNP. Methyltriclosan was shown to increase the rate of hydrogen peroxide production by rat liver mitochondria. In addition, methyltriclosan induces permeabilization of both mitochondrial membranes and the liposome membranes. Methyltriclosan, in contrast to triclosan, has a milder effect on organelles and their membranes. Possible mechanisms of methyltriclosan effects on mitochondria and liposomes are discussed.

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ACKNOWLEDGMENTS

The work was supported by grant from the Russian Foundation for Basic Research (20-015-00124) and by the grant of the President of the Russian Federation (MK-61.2019.4).

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Authors and Affiliations

  1. Mari State University, 424000, Yoshkar-Ola, Russia

    K. S. Tenkov, M. V. Dubinin, A. A. Semenova & K. N. Belosludtsev

  2. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290, Pushchino, Moscow oblast, Russia

    K. N. Belosludtsev

  3. Prokhorov General Physics Institute, Russian Academy of Sciences, 119991, Moscow, Russia

    K. N. Belosludtsev

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  1. K. S. Tenkov
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  2. M. V. Dubinin
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  3. A. A. Semenova
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  4. K. N. Belosludtsev
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Correspondence to K. S. Tenkov.

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The authors declare that they have no conflict of interest.

All procedures were performed in accordance with the European Communities Council Directive (November 24, 1986; 86/609/EEC) and the Declaration on humane treatment of animals. The Protocol of experiments was approved by the Commission on Bioethics of the Mari State University.

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Translated by M. Dubinin

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Tenkov, K.S., Dubinin, M.V., Semenova, A.A. et al. Effect of Methyltriclosan on the Functioning of Isolated Rat Liver Mitochondria and Permeability of Liposomal Membranes. Biochem. Moscow Suppl. Ser. A 15, 147–155 (2021). https://doi.org/10.1134/S1990747821020082

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  • DOI: https://doi.org/10.1134/S1990747821020082

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