Skip to main content
Log in

Models of regulation of stem cell niche structure in shoot apical meristem

  • Published:
Russian Journal of Genetics: Applied Research

Abstract

The experimental data obtained to date has provided grounds for certain concepts of stem cell niche regulation in shoot apical meristem (SAM). Mathematical modeling is used to check their consistency and coherence with the experimental data. In this paper, we summarize mathematical models of stem cell niche structure regulation proposed by different authors, analyze the experimental base and working hypotheses formalized in these models, and identify methodological differences in the approaches to the construction of these models.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Barton, M.K., Twenty years on: the inner workings of the shoot apical meristem, a developmental dynamo, Dev. Biol., 2010, vol. 341, pp. 95–113.

    Article  CAS  PubMed  Google Scholar 

  • Bowman, J.L. and Eshed, Y., Formation and maintenance of the shoot apical meristem, Trends Plant Sci, 2000, vol. 5, pp. 110–115.

    Article  CAS  PubMed  Google Scholar 

  • Brand, U., Fletcher, J.C., Hobe, M., et al., Dependence of stem cell fate in Arabidopsis on a feedback loop regulated by CLV3 activity, Science, 2000, vol. 289, pp. 617–619.

    CAS  PubMed  Google Scholar 

  • Brand, U., Hobe, M., and Simon, R., Functional domains in plant shoot meristems, BioEssays, 2001, vol. 23, pp. 134–141.

    CAS  PubMed  Google Scholar 

  • Brand, U., Grunewald, M., Hobe, M., and Simon, R., Regulation of CLV3 expression by two homeobox genes in Arabidopsis, Plant Physiol., 2002, vol. 129, pp. 565–575.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Chickarmane, V.S., Gordon, S.P., Tarr, P.T., et al., Cytokinin signaling as a positional cue for patterning the apical-basal axis of the growing Arabidopsis shoot meristem, Proc. Natl. Acad. Sci. U.S.A., 2012, vol. 109, no. 10, pp. 4002–4007.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Choob, V.V. and Sinyushin, A.A., Flower and shoot fasciation: from phenomenology to the construction of models of apical meristem transformations, Russ. J. Plant Physiol., 2012, vol. 59, no. 4, pp. 530–545.

    CAS  Google Scholar 

  • Fujita, H., Toyokura, K., Okada, K., and Kawaguchi, M., Reaction-diffusion pattern in shoot apical meristem of plants, PLoS ONE, 2011, vol. 6, p. el8243.

    Google Scholar 

  • Geier, F., Lohmann, J.U., Gerstung, M., et al., A quantitative and dynamic model for plant stem cell regulation, PLoS ONE, 2008, vol. 3, p. e3553.

    PubMed Central  PubMed  Google Scholar 

  • Gordon, S.P., Chickarmane, V.S., Ohno, C., and Meyerowitz, E.M., Multiple feedback loops through cytokine in signaling control stem cell number within the Arabidopsis shoot meristem, Proc. Natl. Acad. Sci. U.S.A., 2009, vol. 106, pp. 16529–16534.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Gross-Hardt, R. and Laux, T., Stem cell regulation in the shoot meristem, J. Cell Sci., 2003, vol. 116, pp. 1659–1666.

    CAS  PubMed  Google Scholar 

  • Hohm, T., Zitzler, E., and Simon, R., A dynamic model for stem cell homeostasis and patterning in Arabidopsis meristems, PLoS ONE, 2010, vol. 5, p. e9189.

    PubMed Central  PubMed  Google Scholar 

  • Jonsson, H., Shapiro, B., Meyerowitz, E., and Mjolsness, E., Signaling in multicellular models of plant development, in On Growth Form and Computers, Kumar, S. and Bentley, P., Eds., London: Acad. Press, 2003, pp. 156–161.

    Google Scholar 

  • Jonsson, H., Heisler, M., Reddy, G.V., et al., Modeling the organization of the WUSCHEL expression domain in the shoot apical meristem, Bioinformatics, 2005, vol. 21,suppl. 1, pp. i232–i240.

    PubMed  Google Scholar 

  • Jonsson, H., Gruel, J., Krupinski, P., and Troein, C., On evaluating models in computational morphodynamics, Curr. Opin. Plant Biol., 2012, vol. 15, pp. 103–110.

    PubMed  Google Scholar 

  • Kerstetter, R.A., Bollman, K., Taylor, R.A., et al., KANADI regulates organ polarity in Arabidopsis, Nature, 2001, vol. 411, pp. 706–709.

    CAS  PubMed  Google Scholar 

  • Kwiatkowska, D., Structural integration at the shoot apical meristem: models, measurements, and experiments, Am. J. Bot., 2004, vol. 91, pp. 1277–1293.

    PubMed  Google Scholar 

  • Lenhard, M. and Laux, T., Stem cell homeostasis in the Arabidopsis shoot meristem is regulated by intercellular movement of CLAVATA3 and its sequestration by CLAVATA1, Development, 2003, vol. 130, pp. 3163–3173.

    CAS  PubMed  Google Scholar 

  • Mjolsness, E., Sharp, D.H., and Reinitz, J., A connectionist model of development, J. Theor. Biol., 1991, vol. 152, pp. 429–453.

    CAS  PubMed  Google Scholar 

  • Newman, I.V., Pattern in the meristems of vascular plants. III. Pursuing the patterns in the apical meristem where no cell is a permanent cell, J. Linn. Soc. (Botany), 1965, vol. 59, pp. 185–214.

    Google Scholar 

  • Nikolaev, S.V., Kolchanov, N.A., Fadeev, S.I., et al., Study of one-dimensional model of regulation of meristem zone size in biological tissue, Vychisl. Tekhnol., 2006, vol. 11, no. 2, pp. 67–81.

    Google Scholar 

  • Nikolaev, S.V., Penenko, A.V., Lavrekha, V.V., et al., A model study of the role of proteins CLV1, CLV2, CLV3, and WUS in regulation of the structure of the shoot apical meristem, Russ. J. Dev. Biol., 2007, vol. 38, no. 6, pp. 383–388.

    CAS  Google Scholar 

  • Nikolaev, S.V., Zubairova, U.S., Fadeev, S.I., et al., Study of one-dimensional model of regulation of the meristem zone size in biological tissue with allowance for cell division, Sib. Zh. Industr. Mat., 2010, vol. 13, no. 4(44), pp. 70–82.

    Google Scholar 

  • Nikolaev, S.V., Zubairova, U.S., Penenko, A.V., et al., Model of structuring the stem cell niche in shoot apical meristem of Arabidopsis thaliana, Dokl. Biol. Sci., 2013, vol. 452, pp. 316–319.

    CAS  PubMed  Google Scholar 

  • Ogawa, M., Shinohara, H., Sakagami, Y., and Matsubayashi, Y., Arabidopsis CLV3 peptide directly binds CLV1 ectodomain, Science, 2008, vol. 319, p. 294.

    CAS  PubMed  Google Scholar 

  • Reddy, V.G. and Meyerowitz, E.M., Stem-cell homeostasis and growth dynamics can be uncoupled in the Arabidopsis shoot apex, Science, 2005, vol. 310, no. 5748, pp. 663–667.

    CAS  PubMed  Google Scholar 

  • Rojo, E., Sharma, V.K., Kovaleva, V., et al., CLV3 is localized to the extracellular space, where it activates the Arabidopsis clavata stem cell signaling pathway, Plant Cell, 2002, vol. 14, pp. 969–977.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Sablowski, R., Plant stem cell niches: from signalling to execution, Curr. Opin. Plant Biol., 2011, vol. 14, pp. 4–9.

    CAS  PubMed  Google Scholar 

  • Sahlin, P. and Melke, P., Models of sequestration and receptor cross-talk for explaining multiple mutants in plant stem cell regulation, BMC Syst. Biol., 2011, vol. 5, p. 2.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Schoof, H., Lenhard, M., Haecker, A., et al., The stem cell population of Arabidopsis shoot meristems in maintained by a regulatory loop between the clavata and wuschel genes, Cell, 2000, vol. 100, pp. 635–644.

    CAS  PubMed  Google Scholar 

  • Sharma, V.K., Carles, C., and Fletcher, J.C., Maintenance of stem cell populations in plants, Proc. Natl. Acad. Sci. U.S.A., 2003, vol. 100.

  • Traas, J. and Doonan, J.H., Cellular basis of shoot apical meristem development, Int. Rev. Cytol., 2001, vol. 208, pp. 161–206.

    CAS  PubMed  Google Scholar 

  • Williams, L. and Fletcher, J.C., Stem cell regulation in the Arabidopsis shoot apical meristem, Curr. Opin. Plant Biol., 2005, vol. 8, pp. 582–586.

    CAS  PubMed  Google Scholar 

  • Yadav, R.K., Girke, T., Pasala, S., et al., Gene expression map of the Arabidopsis shoot apical meristem stem cell niche, Proc. Natl. Acad. Sci. U.S.A., 2009, vol. 106, pp. 4941–4946.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Yadav, R.K., Perales, M., Gruel, J., et al., WUSCHEL protein movement mediates stem cell homeostasis in the Arabidopsis shoot apex, Genes Dev., 2011, vol. 25, pp. 2025–2030.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Yadav, R.K., Perales, M., Gruel, J., et al., Plant stem cell maintenance involves direct transcriptional repression of differentiation program, Mol. Syst. Biol., 2013, vol. 9, p. 654.

    PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to U. S. Zubairova.

Additional information

Original Russian Text © U.S. Zubairova, S.V. Nikolaev, 2013, published in Vavilovskii Zhurnal Genetiki i Selektsii, 2013, Vol. 17, No. 4/1, pp. 738–747.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zubairova, U.S., Nikolaev, S.V. Models of regulation of stem cell niche structure in shoot apical meristem. Russ J Genet Appl Res 4, 273–280 (2014). https://doi.org/10.1134/S2079059714040121

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S2079059714040121

Keywords

Navigation