Skip to main content
Log in

Association of polymorphism of angiotensin-converting enzyme gene I/D and D442G cholesterol ester transfer protein gene with risk factors for atherosclerosis among elderly and senile patients with coronary heart disease in the republic of Sakha (Yakutia)

  • Published:
Advances in Gerontology Aims and scope Submit manuscript

Abstract

A comparative analysis was performed for frequency distribution of I/D polymorphism of angiotensin-converting enzyme (ACE) gene and D442G polymorphism of cholesterol ester transfer protein (CETP) gene in elderly and senile patients and long-lived patients with CHD with regard to ethnicity, age, and gender. The frequency of ACE*I/*I genotype reduces with age; the tendency towards increased proportion of ACE*D/*D genotype was observed. During the comparative analysis of ACE*D/*D and ACE*D/*I genotypes, gender differences were found in frequency of homozygous ACE*D/*D genotype. The carriers of ACE*D/D genotype were identified significantly more often among men than among women. Among all patients and especially among Yakuts, left ventricular hypertrophy confirmed by Sokolov-Lyon index for ECG was observed significantly more often in carriers of ACE*I/*I genotype. During the study of D442G polymorphism of CETP gene, the carriers of CETP*D/*G genotype were identified significantly more often among Yakuts than among nonindigenous individuals. During the comparison of frequencies of I/D polymorphism of the ACE gene, significant differences were observed with respect to body mass index (BMI) and blood lipids. In comparison of CETP*D/*D and CETP*D/*G genotypes, no significant association with CHD risk factor was found.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Akberov, R.F., Sharafeev, A.Z., Mikhailov, M.K., et al., Progressivnyi mul’tifokal’nyi ateroscleroz: etiologiya, kliniko-luchevaya diagnostika, sovremennye aspecty lecheniya (Progressive Multifocal Atherosclerosis: Etiology, Clinical and X-ray Diagnostics, and Modern Methods of Treatment), Kazan: Ideal-Press, 2008.

    Google Scholar 

  2. Anisimov, V.N., Molekulyarnye i fiziologicheskie mekhanizmy stareniya (Molecular and Physiological Mechanisms of Senescence), St. Petersburg: Nauka, 2008, vol. 1.

    Google Scholar 

  3. Vorob’ev, P.A. and Gorokhova, S.G., Coronary heart disease in old age, Klin. Gerontol., 2002, no. 7, pp. 28–33.

    Google Scholar 

  4. Grigor’eva, L.V., Arkhipova, N.S., Popova, E.K., et al., Study of polymorphism of gene D442G of cholesterol ether protein transmitter in Yakuts depending on age: health and life quality of old people of Yakutia, in Mater. mezhreg. nauchno-prakt. konf. (Proc. Interregional Scientific-Practical Conference), Yakutsk, 2010, pp. 60–61.

    Google Scholar 

  5. Demograficheskii ezhegodnik Respubliki Sakha (Yakutiya) (Demographic Yearbook of Sakha Republic), Yakutia: Goskomstat Resp. Sakha, 2006.

  6. Diagnostics and correction of failures of lipid metabolism for prophylactics and treatment of atherosclerosis: Recommendations for Russia (IV revision), Kardiovask. Ter. Profil., 2009, no. 8(6), suppl. 3.

  7. Malygina, N.A., Kostomarova, I.V., Melent’ev, A.S., et al., A link between polymorphism of gene of angiotensin-converting enzyme with inherited predisposition to myocardial infarction, Klin. Med., 2002, no. 8, pp. 25–29.

    Google Scholar 

  8. Moiseev, V.S., Demurov, L.M., Kobalava, Zh.D., et al., Gene polymorphism of angiotensin-converting enzyme in patients with hypertension, left ventricular hypertrophy and development of myocardial infarction in young age, Ter. Arkh., 1997, no. 9, pp. 18–23.

    Google Scholar 

  9. Saigitov, R.T., Glezer, M.G., Sementsov, D.P., et al., Gene I/D polymorphism of angiotensin-converting enzyme in patients with acute coronary syndrome, Kardiovask. Ter. Profil., 2006, no. 8, pp. 34–41.

    Google Scholar 

  10. Bello, N. and Mosca, L., Epidemiology of coronary heart disease in women, Progr. Cardiovasc. Dis., 2004, vol. 46, no. 4, pp. 287–295.

    Article  Google Scholar 

  11. Kamitani, A., Rakugy, H., Higaki, J., et al., Enhanced predictability of myocardial infraction in Japanese by combined genotype analysis, Hypertension, 1995, vol. 25, no. 5, pp. 950–953.

    Article  PubMed  CAS  Google Scholar 

  12. Prasad, N., O’Kane, K.P., Johnstone, H.A., et al., The relationship between blood pressure and left ventricular mass in essential hypertension is observed only in the presence of the angiotensin-converting enzyme gene deletion allele, Quart. J. Med., 1994, vol. 87, no. 11, pp. 659–662.

    CAS  Google Scholar 

  13. US Department of Health and Human Services. Healthy People 2010: Understanding and Improving Health, Washington: U.S. Government Printing Office, 2000.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. L. Ariev.

Additional information

Original Russian Text © N.S. Arkhipova, A.L. Ariev, E.K. Popova, L.V. Grigorieva, L.S. Kozina, 2013, published in Uspekhi Gerontologii, 2013, Vol. 26, No. 1, pp. 76–81.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Arkhipova, N.S., Ariev, A.L., Popova, E.K. et al. Association of polymorphism of angiotensin-converting enzyme gene I/D and D442G cholesterol ester transfer protein gene with risk factors for atherosclerosis among elderly and senile patients with coronary heart disease in the republic of Sakha (Yakutia). Adv Gerontol 3, 277–281 (2013). https://doi.org/10.1134/S2079057013040024

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S2079057013040024

Keywords

Navigation