Abstract
A comparative analysis was performed for frequency distribution of I/D polymorphism of angiotensin-converting enzyme (ACE) gene and D442G polymorphism of cholesterol ester transfer protein (CETP) gene in elderly and senile patients and long-lived patients with CHD with regard to ethnicity, age, and gender. The frequency of ACE*I/*I genotype reduces with age; the tendency towards increased proportion of ACE*D/*D genotype was observed. During the comparative analysis of ACE*D/*D and ACE*D/*I genotypes, gender differences were found in frequency of homozygous ACE*D/*D genotype. The carriers of ACE*D/D genotype were identified significantly more often among men than among women. Among all patients and especially among Yakuts, left ventricular hypertrophy confirmed by Sokolov-Lyon index for ECG was observed significantly more often in carriers of ACE*I/*I genotype. During the study of D442G polymorphism of CETP gene, the carriers of CETP*D/*G genotype were identified significantly more often among Yakuts than among nonindigenous individuals. During the comparison of frequencies of I/D polymorphism of the ACE gene, significant differences were observed with respect to body mass index (BMI) and blood lipids. In comparison of CETP*D/*D and CETP*D/*G genotypes, no significant association with CHD risk factor was found.
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Original Russian Text © N.S. Arkhipova, A.L. Ariev, E.K. Popova, L.V. Grigorieva, L.S. Kozina, 2013, published in Uspekhi Gerontologii, 2013, Vol. 26, No. 1, pp. 76–81.
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Arkhipova, N.S., Ariev, A.L., Popova, E.K. et al. Association of polymorphism of angiotensin-converting enzyme gene I/D and D442G cholesterol ester transfer protein gene with risk factors for atherosclerosis among elderly and senile patients with coronary heart disease in the republic of Sakha (Yakutia). Adv Gerontol 3, 277–281 (2013). https://doi.org/10.1134/S2079057013040024
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DOI: https://doi.org/10.1134/S2079057013040024