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The genetic certificate is the basic contributor to active longevity and long lifespan

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Abstract

A genetic certificate is a DNA database reflecting the specific features of a personal genome. The review considers the concept of individual genetic certificates and their significance for prolongation of active longevity and for paving the way to the longest possible lifespan. The involvement of the biological clock and weak link genes in aging processes in human beings is outlined. The significance of genetic tests for allelic polymorphisms and marker genes associated with common multifactorial disorders is stressed. Special attention is paid to the Genome Wide Association Studies technology implemented for analysis of genetic profiles and candidate genes associated with common diseases. Relevant scientific problems are discussed, as well as the public interest in creation of personalized DNA databanks (genetic certificates) for pregnant women, children, athletes, etc. The relationship of the genetic certificate concept to the current international Personal Genome Project is highlighted. The prospects of the introduction of genetic certificates into medical practice are discussed in the context of gerontological problems.

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References

  1. Prenatal’naya diagnostika nasledstvennykh i vrozhdennykh boleznei (Prenatal Diagnostics of Inherited and Congenital Diseases), Ailamazyan, E.K. and Baranov, V.S., Eds., Moscow: MEDPress Inform, 2006.

    Google Scholar 

  2. Anisimov, V.N., Molekularnye i fiziologicheskie mekhanizmy stareniya (Molecular and Physiological Aging Mechanisms), St. Petersburg: Nauka, 2003.

    Google Scholar 

  3. Anisimov, V.N., Melatonin. Rol’ v organizme, primenenie v klinike (Melatonin: Role in the Body and Clinical Use), St. Petersburg: Sistema, 2007.

    Google Scholar 

  4. Anisimov, V.N., Baranov, V.S., Khavinson, V.Kh, et al., Profilaktika vozrastnoi patologii i uskorennogo stareniya, snizhenie prezhdevremennoi smertnosti ot biologicheskikh prichin i prodlenie trudosposobnogo perioda zhizni nasleniya: Metod. rekom. (Guidelines on the Prevention of Age-related Disorders and Premature Aging, Reduction of the Rate of Premature Mortality Caused by Biologic Factors, and Prolongation of the Employable Life of the Population), St. Petersburg: IPK BIONT, 2008.

    Google Scholar 

  5. Baranov, V.S., Human Genome as a Scientific Base of Preventive Medicine, Vestn. Ross. Acad. Med. Nauk, 2000, vol. 10, pp. 27–37.

    Google Scholar 

  6. Baranov, V.S., Genomics is the Base of Gerontology, Breslerovskie chteniya (Bresler Readings), 2007, pp. 178–187.

  7. Baranov, V.S. and Baranova, E.V., Genetic Aspects of Aging, Usp. gerontol., 2007, vol. 20, no. 2, pp. 26–34.

    CAS  Google Scholar 

  8. Baranov, V.S. and Khavinson, V.Kh, Opredelenie geneticheskoi predraspolozhennosti k nekotorym multifaktornym zabolevaniyam. Geneticheskii pasport (Determination of Genetic Predisposition to Some Multifactorial Diseases. Genetic Certificate), St. Petersburg: IKF Foliant, 2001.

    Google Scholar 

  9. Baranov, V.S., Baranova, E.V., Ivashchenko, T.E., and Aseev, M.V., Genom cheloveka i geny predraspolozhennosti. Vvedenie v prediktivnuyu meditsinu (Human Genome and Predisposition Genes. Introduction to Predictive Medicine), St. Petersburg, Intermedika, 2000.

    Google Scholar 

  10. Baranova, E.V., DNK: znakomstvo s soboi, ili Kak prodlit’ molodost’ (DNA: Introduction to Yourself, or How to Prolong Youth), Moscow: AST, Astrel’-SPb, INBIOM, 2006.

    Google Scholar 

  11. Borinskaya, S.B. and Yankovskii, N.K, Lyudi i ikh geny: niti sud’by (People and Their Genes: Threads of Fate), Fryazino, 2006.

  12. Galimova, E.S., Akhmetova, V.L., and Khusnutdinova, E.K., Molecular Genetic Basis of Susceptibility to Psoriasis, Genetika, 2008, vol. 44, no. 5, pp. 594–605 [Russ. J. Genet. (Engl. Transl.), vol. 44, no. 5, pp. 513–522].

    CAS  PubMed  Google Scholar 

  13. Glotov, O.S. and Baranov, V.S., Genetic Polymorphism and Aging, Usp. Gerontol., 2007, vol. 20, no. 2, pp. 35–55.

    CAS  Google Scholar 

  14. Glotov, A.S., Ivashchenko, T.E., Obraztsova, G.I., et al., Association of Permanent Arterial Hypertension with the Renin-Angiotensin and Kinin-Bradykinin System Genes in Children, Molek. Biol., 2007, vol. 41, no. 1, pp. 18–25 [Mol. Biol. (Engl. Transl.), vol. 41, no. 1, pp. 14–21].

    CAS  Google Scholar 

  15. Gerontologiya in silico: stanovlenie novoi distsipliny (In silico Gerontology: Nascence of a Novel Speciality), Marchuk, G.I., Anisimov, V.N., Romanova, A.A., and Yashin, A.I., Eds., Moscow: BINOM, Laboratoriya znanii, 2007.

    Google Scholar 

  16. Moskalev, A.A., Starenie i geny (Aging and Genes), St. Petersburg: Nauka, 2008.

    Google Scholar 

  17. Puzyrev, V.P., Stepanov, V.A., and Freidin, M.B., Molecular Bases of Common Multifactorial Diseases, in Genomika—meditsine (Genomics to Medicine), Moscow: Akademkniga, 2005, pp. 100–150.

    Google Scholar 

  18. Puzyrev, V.P., Freidin, M.B., and Kucher, A.N., Geneticheskoe raznoobrazie narodonaseleniya i bolezni cheloveka (Genetic Diversity of Human Populations and Human Diseases), Tomsk, 2007.

  19. Sinclair, D.G., and Guarente, L., Unlocking the secrets of longevity genes, Scientific American, 2006, vol. 294, no. 3, pp. 54–57.

    Article  Google Scholar 

  20. Khavinson, V.Kh, Anisimov, S.V., Malinin, V.V., and Anisimov, V.N., Peptidnaya regulatsiya genoma i starenie (Peptide-mediated Regulation of the Genome and Aging), Moscow: Izd. RAMN, 2005.

    Google Scholar 

  21. Church, G.M., Genomes for All, Scientific American, 2006, vol. 294, no. 1, pp. 46–54.

    Article  CAS  PubMed  Google Scholar 

  22. Eid. J., Science Advance Online Publication, doi: 10.1126/science, 1162986. (Accessed November 20, 2008).

  23. Graham, E., Rodwell, J., Sonu, R., et al., The Transcriptional Profile of Aging in the Human Kidney, PLoS Biology, 2004, vol. 2, no. 12, pp. 1–23.

    Google Scholar 

  24. Grossman, T., Latest Advances in Antiaging Medicine, Keio J. Med., 2005, vol. 54, pp. 85–94.

    Article  CAS  PubMed  Google Scholar 

  25. Khavinson, V.Kh. and Malinin, V.V., Gerontological Aspects of Genome Peptide Regulation, Karger, Basel, 2005.

  26. Klatz, R., The Anti-aging Medicine, the World’s Fastest Growing Medical Speciality, J. Eur. Antiaging Med., 2005, no. 1, pp. 10–12.

  27. Meltzer, D., Hogarth, St., Liddel, K., et al., Genetic Tests for Common Diseases: New Insights, Old Concerns, Brit. Med. J., 2008, vol. 336, pp. 590–593.

    Article  Google Scholar 

  28. Seng, K.Ch. and Seng, Ch.K., The Success of the Genome — Wide Association Approach: a Brief Story of Long Struggle, Eur. J. Hum. Genet., 2008, vol. 16., pp. 554–564.

    Article  PubMed  Google Scholar 

  29. Wel, M., Fabrizio, P., Hu, J., et al., Life Span Extension by Calorie Restriction Depends on Rim 15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9, PLoS Genet., vol. 4, no. 1, e13. doi 10:1371/journal pgen.0040013

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Authors and Affiliations

  1. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, Mendeleevskaya liniya 3, St. Petersburg, 199034, Russia

    V. S. Baranov

  2. European Institute of Personalized Prevention, rue Pastorelli 38, Nice, 06000, France

    E. V. Baranova

Authors
  1. V. S. Baranov
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  2. E. V. Baranova
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Correspondence to V. S. Baranov.

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Original Russian Text © V.S. Baranov, E.V. Baranova, 2009, published in Uspekhi Gerontologii, 2009, Vol. 22, No. 1, pp. 84–91.

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Baranov, V.S., Baranova, E.V. The genetic certificate is the basic contributor to active longevity and long lifespan. Adv Gerontol 1, 152–158 (2011). https://doi.org/10.1134/S2079057011020020

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