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BIODEGRADABLE COMPOSITIONS OF ULTRATHIN POLY-3-HYDROXYBUTYRATE FIBERS WITH MNCL2–TETRAPHENYLPORPHYRIN COMPLEXES. DYNAMICS, STRUCTURE, AND PROPERTIES

  • POLYMER, BIOORGANIC, AND HYBRID NANOMATERIALS
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Abstract

Comprehensive studies combining X-ray structural analysis, structural dynamic measurements with an EPR probe method, thermophysical measurements (DSC), and scanning electron microscopy have been carried out. The specificity of the crystalline and amorphous structure of ultrathin poly-3-hydroxybutyrate fibers containing a low concentration of manganese complex with chlorotetraphenyl porphyrin (MnCl2–TPP) (0–5 wt %), obtained via electroforming, is considered. When PHB of MnCl2–TTP complexes are added to PHB fibers, the morphology of the fibers changes, crystallinity increases, and the molecular mobility in the dense amorphous regions of the polymer slows down. The temperature effect on the fibers (annealing at 140°С) leads to a sharp increase in crystallinity and molecular mobility in the amorphous regions of poly-3-hydroxybutyrate. Exposure of fibers in an aqueous medium at 70°С leads to a sharp decrease in the enthalpy of melting and to an increase in the molecular mobility of the chains in the amorphous regions. The fibrous materials have bactericidal properties and must be directly applied in the creation of therapeutic systems with antibacterial and antitumor action.

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ACKNOWLEDGMENTS

We thank S.N. Chvalun, A.N. Bakirov for the XRD studies of PHB/MnCl2–TPP fibers, and Prof. U.J. Haenggi (Biomer®, Krailling, Germany) for providing poly-3-hydroxybutyrate.

Funding

We used equipment from the Center for Collective Use “New materials and technologies” of the Emanuel Institute of Biochemical Physics, RAS. The spectral and calorimetric studies were completed at the N.N. Semenov Institute of Chemical Physics, RAS, under the terms of the RF Ministry of Education and Science Government task (nos. AAAA-A18-118020890097-1 and AAAA-A17-117040610309-0).

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Authors and Affiliations

  1. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia

    S. G. Karpova & A. A. Ol’khov

  2. Plekhanov Russian University of Economics, 117997, Moscow, Russia

    A. A. Ol’khov, A. V. Lobanov & A. A. Popov

  3. Semenov Institute of Chemical Physics, Russian Academy of Sciences, 117997, Moscow, Russia

    A. V. Lobanov & A. L. Iordanskii

Authors
  1. S. G. Karpova
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  2. A. A. Ol’khov
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  3. A. V. Lobanov
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  4. A. A. Popov
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  5. A. L. Iordanskii
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Correspondence to S. G. Karpova.

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Translated by P. Vlasov

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Karpova, S.G., Ol’khov, A.A., Lobanov, A.V. et al. BIODEGRADABLE COMPOSITIONS OF ULTRATHIN POLY-3-HYDROXYBUTYRATE FIBERS WITH MNCL2–TETRAPHENYLPORPHYRIN COMPLEXES. DYNAMICS, STRUCTURE, AND PROPERTIES. Nanotechnol Russia 14, 132–143 (2019). https://doi.org/10.1134/S1995078019020083

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