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Determination of the Spatial Structure of Lidocaine in SC-CO2 by the 2D NOESY Method

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Abstract

This work presents an analysis of the lidocaine spatial structure in SC-CO2. Two-dimensional nuclear Overhauser effect spectroscopy (2D NOESY) and quantum chemical calculations (DFT) were used to identify the preferable conformers in an SC-CO2 solution (70°C, 20 MPa). The data obtained in this work can be used to calculate the optimal micronization parameters by the RESS method.

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ACKNOWLEDGMENTS

This work was supported by the Ministry of Education and Science of the Russian Federation, Russia (contracts nos. 01201260481 and 0120095082), by the Russian Foundation for Basic Research (M.K., grant nos. 18-29-06008 and 20-43-370011) and Council for Grants of the President of the Russian Federation, Russia (I.K., project МК-662.2021.1.3). The NMR spectroscopy experiment was performed using the molecular fluid spectroscopy facility (http://www.ckp-rf.ru/usu/503933/) of G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences (ISC RAS), Ivanovo, Russia.

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  1. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo, Russia

    K. V. Belov, A. A. Dyshin, M. G. Kiselev, M. A. Krestyaninov, V. V. Sobornova & I. A. Khodov

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  1. K. V. Belov
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  2. A. A. Dyshin
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  3. M. G. Kiselev
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  4. M. A. Krestyaninov
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  5. V. V. Sobornova
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  6. I. A. Khodov
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Correspondence to I. A. Khodov.

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Belov, K.V., Dyshin, A.A., Kiselev, M.G. et al. Determination of the Spatial Structure of Lidocaine in SC-CO2 by the 2D NOESY Method. Russ. J. Phys. Chem. B 15, 1303–1309 (2021). https://doi.org/10.1134/S1990793121080145

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  • DOI: https://doi.org/10.1134/S1990793121080145

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