Abstract
The effects of exercise stress following single semax and selank administration on the activity of carboxypeptidase E and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase, which are basic carboxypeptidases that are involved in the final stage of processing of biologically active neuropeptide precursors, was studied. The enzyme activity was shown to increase during exercise stress, as well as in response to administration of the peptide agents prior to exercise. The role of basic carboxypeptidases in the mechanisms of semax- and selank-induced stimulation and in the activation of the peptidergic system during physical exercise is discussed.
Similar content being viewed by others
References
Jonsdottir, I.H., Immunology Cell Biology, 2000, vol. 78, pp. 562–570.
Kraemer, W.J. and Rogol, A.D., The Endocrine System in Sports and Exercise, Wiley, 2005.
Hoene, M. and Weigert, C., Exerc. Immunol. Rev., 2010, vol. 16, pp. 163–183.
Ying, R.R., Roy, H., Zhong, S., Zdunowski, V.R., Edgerton, F., and Gomez-Pinilla, A., Neurosci., 2008, vol. 155, no. 4, pp. 1070–1078.
Pritchard, L.E. and White, A., Endocrinology, 2008, vol. 148, no. 9, pp. 4201–4207.
Gengin, M.T., Characteristics of structural and functional organization and physicochemical properties of nonlysosomal peptide hydrolases of the animal brain, Extended Abstract of Doctoral (Biol.) Dissertation, Penza, 2002.
Solov’ev, V.B., Role of the peptidergic system in adaptation processes and metabolism regulation during physical exercise, Extended Abstract of Doctoral (Biol.) Dissertation, Moscow, 2011.
Solov’ev, V.B., Gengin, M.T., Sollertinskaya, T.N., Latynova, I.V., and Zhivaeva L.V., J. Evol. Biochem. Physiol., 2012, vol. 48, no. 3, pp. 254–257.
Solov’ev, V.B., Gengin, M.T., Sollertinskaya, T.N., Latynova, I.V., and Zhivaeva L.V., Neurochem. J., 2011, vol. 28, no. 2, pp. 169–172.
Krasnova, A.F., Samodanova, G.I., Usik, S.V., and Yakovlev, N.N., Physiol. Zh. USSR, 1977, vol. 63, no. 6, pp. 864–871.
Supattapone, S., Fricker, L.D., and Snyder, S.H., Neurochem., 1984, vol. 42, no. 4, pp. 1017–1023.
Gengin, M.T. and Solov’ev, V.B., Neurochem. J., 2007, vol. 24, no. 2, pp. 138–142.
Lakin, G.F., Biometriya (Biometry), Moscow Vysshaya shkola, 1990.
Kerr, A.L. and Swain, R.A., Behav. Neurosci., 2011, vol. 125, no. 1, pp. 1–9.
Dobolyi, A. and Palkovits, M., J. Comp. Neurol., 2008, vol. 507, no. 3, pp. 1393–1408.
Vernigora, A.N. and Gengin, M.T., Ukr. Biokhim. Zh., 2004, vol. 76, no. 3, pp. 68–73.
Tsigos, C. and Chrousos, G.P., J. Psychosom. Res., 2002, vol. 53, no. 4, pp. 865–871.
Fricker, L.D., Peptide Processing Exopeptidases: Amino- and Carboxy-Peptidases Involved with Peptide Biosynthesis, Peptide Biosynthesis and Processing, Fricker L.D., Ed., Boca Raton, Florida: CRC Press, 1991, pp. 199–230.
Song, L. and Fricker, L.D., J. Biol. Chem., 1995, vol. 270, no. 14, pp. 7963–7967.
Jung, Y.K., Kunczt, C.J., Pearson, R.K., Dixon, J.E., and Fricker, L.D., Mol. Endocrinol., 1991, vol. 5, no. 9, pp. 1257–1268.
Myasoedov, N.F., Skvortsova, V.I., Nasonov, E.L., Zhuravleva, E.I., Grivennikov, I.A., Arsen’eva, E.L., and Sukhanov, I.I., Zh. Nevrol. Psikhiatr., 1999, vol. 99, no. 5, pp. 15–19.
Semenova, T.P., Kozlovskaya, M.M., Zuikov, A.V., and Kozloskii, I.I., Biol. Narkol. Med., 2006, vol. 140, no. 6, pp. 658–660.
Bruchas, M.R., Xu, M., and Chavkin, C., Neuroreport., 2008, vol. 19, pp. 1417–1422.
Millan, M.J. and Emrich, H.M., Psychother. Psychosomat., 1981, vol. 36, no. 1, pp. 43–56.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © V.B. Solov’ev, M.T. Gengin, A.A. Stolyarov, O.V. Solov’eva, M.M. Begutov, O.D. Lyubchenko, 2016, published in Neirokhimiya, 2016, Vol. 33, No. 1, pp. 70–75.
Rights and permissions
About this article
Cite this article
Solov’ev, V.B., Gengin, M.T., Stolyarov, A.A. et al. The activities of basic carboxypeptidases in the nervous system of rats during exercise stress and in response to semax and selank. Neurochem. J. 10, 59–63 (2016). https://doi.org/10.1134/S1819712416010141
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1819712416010141