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Intranasal administration: a prospective drug delivery route to the brain

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Abstract

In recent decades the interest in intranasal drug administration is increased, not only for the treatment of acute and chronic diseases of the nasal cavity but mainly for drug delivery to the brain. The advantages of intranasal drug delivery (IDD) are the high bioavailability of drugs, rapid development of therapeutic effects, non-invasiveness, painlessness, and simple and comfortable application. In order to reach a high extent and rate of drug absorption and bioavailability, various approaches have been suggested, including application of micro- and nanocarriers. Intranasal administration is used for a wide variety of drugs, including proteins, peptides, and highly polar compounds. The opportunity to use IDD to the brain opens new promise for the effective treatment of cerebral pathologies.

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  1. T. V. Bukreeva

    Present address: , Leninskii prospect 59, Moscow, 119333, Russia

Authors and Affiliations

  1. National Research Center Kurchatov Institute, Moscow, Russia

    A. M. Privalova & T. V. Bukreeva

  2. Shubnikov Institute of Cristallography, Russian Academy of Sciences, Moscow, Russia

    A. M. Privalova & T. V. Bukreeva

  3. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

    N. V. Gulyaeva

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Original Russian Text © A.M. Privalova, N.V. Gulyaeva, T.V. Bukreeva, 2012, published in Neirokhimiya, 2012, Vol. 29, No. 2, pp. 93–105.

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Privalova, A.M., Gulyaeva, N.V. & Bukreeva, T.V. Intranasal administration: a prospective drug delivery route to the brain. Neurochem. J. 6, 77–88 (2012). https://doi.org/10.1134/S1819712412020080

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