Abstract
In this article, the effect of surgical damage to the nasal mucosa in rats under the action of general anesthesia was investigated. The motor activity and heart rate variability (HRV) of rats were studied before and 2 days after the surgery. After surgical exposure, motor activity decreased, the time of fading and grooming increased, VLF increased, and HF decreased. Surgical trauma of the nasal septum in rats at the early postoperative stage promotes a pronounced stress response in the form of a sharp shift in the balance of the autonomic nervous system towards the sympathetic level and causes a decrease in exploratory activity, an anxiety, and a depressive-like state in rats.
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Statement on the welfare of animals. Animal studies were carried out in accordance with the requirements of the Rules for the Use of Experimental Animals (1984) and the European Convention for the Protection of Vertebrate Animals Used for Experiments or for Other Scientific Purposes (1986).
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Kastyro, I.V., Reshetov, I.V., Khamidulin, G.V. et al. The Effect of Surgical Trauma in the Nasal Cavity on the Behavior in the Open Field and the Autonomic Nervous System of Rats. Dokl Biochem Biophys 492, 121–123 (2020). https://doi.org/10.1134/S1607672920030023
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DOI: https://doi.org/10.1134/S1607672920030023