Abstract
Nigrostriatal dopaminergic neurons (DNs), involved in the regulation of motor function, are characterized by a high plasticity. Indeed, at the death of up to 50% of DNs in Parkinson’s disease, the survived neurons provide normal regulation. This study was aimed to determine whether the vesicle cycle proteins, syntaxin Ia (Syn Ia), synaptotagmin I (Syt I), Rab5a, and complexins I and II (Cmpx I and II) are involved in the mechanisms of neuroplasticity in the substantia nigra, which mainly contains cell bodies and processes of the DNs. In the neurotoxic models of Parkinson’s disease in mice, it was shown that, at the degeneration of up to 50% of DNs, the content of Syt I, Syn Ia, and Cmpх I and II, involved in vesicle exocytosis, does not change in the substantia nigra as a whole but is compensatorily increased in individual survived DNs. Thus, the data obtained in this study suggest that the impairment of motor behavior, which occurs at the death of half of the nigrostriatal DNs, is not caused by the impairment of the production of vesicle cycle proteins in the survived DNs.
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This work was supported by the Russian Foundation for Basic Research (project no. 17-04-00479, “Molecular Mechanisms of Brain Neuroplasticity in Functional Impairment (Degeneration) of Dopaminergic Neurons”).
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Statement on the welfare of animals. Manipulation with the mice were conducted in accordance with the protocol approved by the Animal Protection Committee of the Institute of Developmental Biology, Russian Academy of Sciences and were in accordance with the national and international requirements.
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Translated by M. Batrukova
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Mingazov, E., Pavlova, E.N., Surkov, S.A. et al. Proteins of the Vesicular Cycle as a Marker of Neuroplasticity of Dopaminergic Neurons in the Substantia Nigra of the Brain. Dokl Biochem Biophys 489, 399–402 (2019). https://doi.org/10.1134/S1607672919060115
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DOI: https://doi.org/10.1134/S1607672919060115