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Innate Immune Protein Tag7 Stimulates the Appearance of Cytotoxic NK Cells after Incubation with Lymphocytes

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

Tag7 (PGRP-S) is an innate immune protein that is involved in the antibacterial and antitumor defense and stimulates the maturation of cytotoxic lymphocyte subpopulations. It was found that the incubation of lymphocytes with Tag7 for 3 days promotes the appearance of cytotoxic NK cells that are active against a number of tumor cell lines.

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Authors and Affiliations

  1. Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia

    T. N. Sharapova, E. A. Romanova, L. P. Sashchenko,  N. V. Gnuchev & D. V. Yashin

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  1. T. N. Sharapova
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  2. E. A. Romanova
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  3. L. P. Sashchenko
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  4. N. V. Gnuchev
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  5. D. V. Yashin
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Correspondence to T. N. Sharapova.

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Translated by M. Batrukova

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Sharapova, T.N., Romanova, E.A., Sashchenko, L.P. et al. Innate Immune Protein Tag7 Stimulates the Appearance of Cytotoxic NK Cells after Incubation with Lymphocytes. Dokl Biochem Biophys 484, 92–94 (2019). https://doi.org/10.1134/S1607672919010253

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  • DOI: https://doi.org/10.1134/S1607672919010253

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