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The role of production of adipsin and leptin in the development of insulin resistance in patients with abdominal obesity

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

We investigated the tissue-specific features of the production of adipokines (leptin and adipsin) by adipose tissue in obese patients depending on the degree of obesity and the state of carbohydrate metabolism. An increase in the content of adipsin and leptin in the blood plasma was found. In patients with varying degrees of obesity with and without type 2 diabetes mellitus (DM 2), we determined the level of tissue-specific expression of LEP and CFD genes encoding leptin and adipsin, respectively. The contribution of different adipose tissue depots to the blood plasma level of adipsin and leptin in obese patients with and without DM 2 was established. The disturbance of reciprocal relationships between adipsin and leptin in obesity is associated with the development of insulin resistance.

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Authors and Affiliations

  1. Immanuel Kant Baltic Federal University, Kaliningrad, 236041, Russia

    M. A. Vasilenko, E. V. Kirienkova, D. A. Skuratovskaia, P. A. Zatolokin & L. S. Litvinova

  2. Kaliningrad Regional Hospital, Kaliningrad, 236041, Russia

    P. A. Zatolokin & N. I. Mironyuk

Authors
  1. M. A. Vasilenko
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  2. E. V. Kirienkova
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  3. D. A. Skuratovskaia
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  4. P. A. Zatolokin
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  5. N. I. Mironyuk
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  6. L. S. Litvinova
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Corresponding author

Correspondence to L. S. Litvinova.

Additional information

Original Russian Text © M.A. Vasilenko, E.V. Kirienkova, D.A. Skuratovskaia, P.A. Zatolokin, N.I. Mironyuk, L.S. Litvinova, 2017, published in Doklady Akademii Nauk, 2017, Vol. 475, No. 3, pp. 336–341.

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Vasilenko, M.A., Kirienkova, E.V., Skuratovskaia, D.A. et al. The role of production of adipsin and leptin in the development of insulin resistance in patients with abdominal obesity. Dokl Biochem Biophys 475, 271–276 (2017). https://doi.org/10.1134/S160767291704010X

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  • DOI: https://doi.org/10.1134/S160767291704010X

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