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Methyl-β-cyclodextrin inhibits Ca2+-responses induced by glutoxim and molixan in macrophages

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

Using Fura-2AM microfluorimetry, we have shown for the first time that methyl-β-cyclodextrin, inducing cholesterol extraction from membranes and raft disruption, significantly inhibits glutoxim- and molixan-induced Ca2+-responses in rat peritoneal macrophages. The results suggest that intact rafts are necessary for signaling cascade induced by glutoxim or molixan and leading to intracellular Ca2+ concentration increase in macrophages.

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Authors and Affiliations

  1. St. Petersburg State University, Universitetskaya nab. 7/9, St. Petersburg, 199034, Russia

    Z. I. Krutetskaya, L. S. Milenina, A. A. Naumova, S. N. Butov, V. G. Antonov & A. D. Nozdrachev

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  1. Z. I. Krutetskaya
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  2. L. S. Milenina
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  3. A. A. Naumova
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  4. S. N. Butov
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  5. V. G. Antonov
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  6. A. D. Nozdrachev
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Corresponding author

Correspondence to Z. I. Krutetskaya.

Additional information

Original Russian Text © Z.I. Krutetskaya, L.S. Milenina, A.A. Naumova, S.N. Butov, V.G. Antonov, A.D. Nozdrachev, 2016, published in Doklady Akademii Nauk, 2016, Vol. 471, No. 1, pp. 109–111.

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Krutetskaya, Z.I., Milenina, L.S., Naumova, A.A. et al. Methyl-β-cyclodextrin inhibits Ca2+-responses induced by glutoxim and molixan in macrophages. Dokl Biochem Biophys 471, 390–392 (2016). https://doi.org/10.1134/S1607672916060041

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  • DOI: https://doi.org/10.1134/S1607672916060041

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