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Synthesis and biologic properties of new thiazolylbenzodioxane derivatives

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Abstract

Reaction of 4-(1,4-benzodioxan-2-yl)thiazol-2-amine with acid chlorides afforded N-substituted amides which further were reduced into the corresponding amines. A new method was developed of preparation of 2-acetyl-1,4-benzodioxane, the initial compound in the synthesis of thiazolylbenzodioxane and numerous derivatives of this series. The adreno- and sympatholytic as well as antihypoxic effect of the obtained biheterocyclic 1,4-benzodioxane derivatives were investigated.

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Authors and Affiliations

  1. R&D Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of Armenia, Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, Yerevan, 0014, Armenia

    S. O. Vartanyan, A. S. Avakyan, A. B. Sargsyan, S. A. Arutyunyan, O. S. Noravyan & A. S. Tsatinyan

Authors
  1. S. O. Vartanyan
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  2. A. S. Avakyan
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  3. A. B. Sargsyan
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  4. S. A. Arutyunyan
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  5. O. S. Noravyan
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  6. A. S. Tsatinyan
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Corresponding author

Correspondence to S. O. Vartanyan.

Additional information

Original Russian Text © S.O. Vartanyan, A.S. Avakyan, A.B. Sargsyan, S.A. Arutyunyan, О.S. Noravyan, A.S. Tsatinyan, 2016, published in Zhurnal Organicheskoi Khimii, 2016, Vol. 52, No. 2, pp. 261–265.

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Vartanyan, S.O., Avakyan, A.S., Sargsyan, A.B. et al. Synthesis and biologic properties of new thiazolylbenzodioxane derivatives. Russ J Org Chem 52, 244–248 (2016). https://doi.org/10.1134/S1070428016020159

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  • DOI: https://doi.org/10.1134/S1070428016020159

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