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Synthesis of epothilone D with the forced application of oxycyclopropane intermediates

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Abstract

The total synthesis of epothilone D with six-fold application in the intermediate stages of successive cyclopropanation — opening or cleavage of the three-membered ring was performed. These transformations underlie the new stereoselective method developed for coupling fragments C7–C12 and C13–C21 in the target molecule.

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Authors and Affiliations

  1. Belorussian State University, Minsk, 220030, Belarus’

    A. L. Hurski & O. G. Kulinkovich

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  1. A. L. Hurski
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  2. O. G. Kulinkovich
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Correspondence to O. G. Kulinkovich.

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Dedicated to Academician O.M. Nefedov on occasion of his 80th anniversary

Original Russian Text © A.L. Hurski, O.G. Kulinkovich, 2011, published in Zhurnal Organicheskoi Khimii, 2011, Vol. 47, No. 11, pp. 1623–1642

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Hurski, A.L., Kulinkovich, O.G. Synthesis of epothilone D with the forced application of oxycyclopropane intermediates. Russ J Org Chem 47, 1653–1674 (2011). https://doi.org/10.1134/S1070428011110029

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