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Experimental photodynamic therapy: 15 years of development

  • Supplement: Rossiiskii Khimicheskii Zhurnal-Zhurnal Rossiiskogo Khimicheskogo Obshchestva im. D.I. Mendeleeva (Russian Chemistry Journal)
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Abstract

Photodynamic therapy and fluorescence diagnosis of malignant tumors have been actively developed over the last 15 years by the scientists participating in the Moscow Government-funded “Fight against Cancer” program. New effective photosensitizers absorbing in the long-wave spectral region were revealed. Unique agents Alasens-lio, Alasens-gel, Hexasens-lio, Phthalosens-lio, Holosens-lio, and Holosensgel were produced and preclinically studied both in vitro and in vivo. New methods using low-intensity and pulse modes of irradiation and also combined methods of treatment by photodynamic therapy and well-known chemotherapy or laser hyperthermia were developed. Methodological recommendations for experimental studies of agents with photoinduced antitumor properties were published.

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Authors and Affiliations

  1. Herzen Moscow Research Oncological Institute, 2-i Botkinskii proezd 3, Moscow, 125284, Russia

    R. I. Yakubovskaya, N. B. Morozova, A. A. Pankratov, N. I. Kazachkina, A. D. Plyutinskaya, T. A. Karmakova, T. N. Andreeva, Yu. B. Venediktova, E. A. Plotnikova, E. R. Nemtsova, V. V. Sokolov, E. V. Filonenko & V. I. Chissov

  2. Research Institute of Organic Intermediates and Dyes, State Scientific Center, Federal State Unitary Enterprise, Bol’shaya Sadovaya ul. 1, str. 4, Moscow, 123995, Russia

    B. Ya. Kogan & A. V. Butenin

  3. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117871, Russia

    A. V. Feofanov

  4. Lomonosov Moscow State University, Moscow, 119991, Russia

    A. V. Feofanov & M. G. Strakhovskaya

Authors
  1. R. I. Yakubovskaya
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  2. N. B. Morozova
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  3. A. A. Pankratov
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  4. N. I. Kazachkina
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  5. A. D. Plyutinskaya
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  6. T. A. Karmakova
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  7. T. N. Andreeva
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  8. Yu. B. Venediktova
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  9. E. A. Plotnikova
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  10. E. R. Nemtsova
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  11. V. V. Sokolov
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  12. E. V. Filonenko
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  13. V. I. Chissov
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  14. B. Ya. Kogan
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  15. A. V. Butenin
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  16. A. V. Feofanov
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  17. M. G. Strakhovskaya
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Corresponding author

Correspondence to R. I. Yakubovskaya.

Additional information

Original Russian Text © R.I. Yakubovskaya, N.B. Morozova, A.A. Pankratov, N.I. Kazachkina, A.D. Plyutinskaya, T.A. Karmakova, T.N. Andreeva, Yu.B. Venediktova, E.A. Plotnikova, E.R. Nemtsova, V.V. Sokolov, E.V. Filonenko, V.I. Chissov, B.Ya. Kogan, A.V. Butenin, A.V. Feofanov, M.G. Strakhovskaya, 2013, published in Rossiiskii Khimicheskii Zhurnal, 2013, Vol. 57, No. 2, pp. 10–30.

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Yakubovskaya, R.I., Morozova, N.B., Pankratov, A.A. et al. Experimental photodynamic therapy: 15 years of development. Russ J Gen Chem 85, 217–239 (2015). https://doi.org/10.1134/S1070363215010405

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  • DOI: https://doi.org/10.1134/S1070363215010405

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