Abstract
Posttranscriptional regulation of gene expression mediated by small RNAs plays an important role in the virulence of pathogenic microorganisms. We have detected the expression of the following Mycobacterium avium genes situated in intergenic loci and coding for small RNAs: MAV_0380-0381 (4.5S RNA), MAV_1034-1035 (trans-encoded small RNA), MAV_1415-1416 (antisense or trans-encoded small RNA), and MAV_1531-1532 (processed 5′-UTR of the 16S r\(\bar R\)NA gene). The above-named small RNAs are the first members of the small noncoding RNA class detected in M. avium.
Abbreviations
- UTR:
-
untranslated region
- RT-PCR:
-
reverse transcription-PCR
References
Horsburgh, C.R., Jr., The New Eng. J. Med., 1991, vol. 324, p. 1332.
Inderlied, C.B., Kemper, C.A., and Bermudez, L.E., Clin. Microbiol. Rev., 1993, vol. 6, p. 266.
Livny, J. and Waldor, M.K., Curr. Opin. Microbiol., 2007, vol. 10, pp. 96–101.
Sharma, C.M., Hoffmann, S., Darfeuille, F., Reignier, J., Findeiss, S., Sittka, A., Chabas, S., Reiche, K., Hackermuller, J., Reinhardt, R., Stadler, P.F., and Vogel, J., Nature, 2010, vol. 464, pp. 250–255.
Sorek, R. and Cossart, P., Nat. Rev. Genet., 2010, vol. 11, pp. 9–16.
Waters, L.S. and Storz, G., Cell, 2009, vol. 136, pp. 615–628.
Toledo-Arana, A., Repoila, F., and Cossart, P., Curr. Opin. Microbiol., 2007, vol. 10, pp. 182–188.
Arnvig, K.B. and Young, D.B., Mol. Microbiol., 2009, vol. 73, pp. 397–408.
DiChiara, J.M., Contreras-Martinez, L.M., Livny, J., Smith, D., McDonough, K.A., and Belfort, M., Nucleic Acids Res., 2010, vol. 38, pp. 4067–4078.
Mandal, M. and Breaker, R.R., Nat. Rev. Mol. Cell Biol., 2004, vol. 5, pp. 451–463.
Gruber, A.R., Lorenz, R., Bernhart, S.H., Neuböck, R., and Hofacker, I.L., Nucleic Acids Res., 2008, vol. 36, pp. W70–W74.
Sandra, L.W., Cell, 1994, vol. 77, pp. 787–790.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © D.V. Ignatov, L.G. Mefodieva, K.B. Majorov, T.A. Skvortsov, T.L. Azhikina, 2012, published in Bioorganicheskaya Khimiya, 2012, Vol. 38, No. 4, pp. 509–512.
Rights and permissions
About this article
Cite this article
Ignatov, D.V., Mefodieva, L.G., Majorov, K.B. et al. Novel small RNAs from Mycobacterium avium . Russ J Bioorg Chem 38, 447–449 (2012). https://doi.org/10.1134/S1068162012040085
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1068162012040085