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Radiopharmaceuticals Based on Alpha Emitters: Preparation, Properties, and Application

  • Medical Physics and Biophysics
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Abstract

In this review, the problems of the development of radiopharmaceuticals (RPs) based on alphaemitting radionuclides are discussed. The prospects of application of the radionuclides 227Th, 225Ac, 223Ra, 213Bi, 212Pb/212Bi, 212Bi, 211At, and 149Tb are estimated in the aspect of their physicochemical properties, such as half-life, properties of daughter radionuclides, and complexing ability. The methods used for the production of radionuclides and their industrial availability are considered. Some examples of radionuclide complexes with ligands and nanoparticles for targeted delivery are presented. The results of medical trials for RPs based on alpha emitters are given.

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Authors and Affiliations

  1. Department of High Energy Chemistry and Radioecology, Mendeleev Russian University of Chemical Technology, Miusskaya pl. 9, Moscow, 125047, Russia

    B. L. Garashchenko & V. A. Korsakova

  2. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, ul. Kosygina 19, Moscow, 119991, Russia

    R. Yu. Yakovlev

  3. Ryazan State Medical University, ul. Vysokovol’tnaya 9, Ryazan, 390026, Russia

    R. Yu. Yakovlev

Authors
  1. B. L. Garashchenko
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  2. V. A. Korsakova
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  3. R. Yu. Yakovlev
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Correspondence to B. L. Garashchenko.

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Original Russian Text © B.L. Garashchenko, V.A. Korsakova, R.Yu. Yakovlev, 2017, published in Yadernaya Fizika i Inzhiniring, 2017, Vol. 8, No. 6, pp. 582–592.

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Garashchenko, B.L., Korsakova, V.A. & Yakovlev, R.Y. Radiopharmaceuticals Based on Alpha Emitters: Preparation, Properties, and Application. Phys. Atom. Nuclei 81, 1515–1525 (2018). https://doi.org/10.1134/S1063778818100071

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