Abstract
The melatonin effect on the anterior and posterior ends of a free-living flatworm Girardia tigrina was studied, as well as the variability of the mitotic activity of the stem cells (neoblasts) in the anterior and posterior postblasteme. This hormone may inhibit the regeneration of the anterior end of the animal in the physiologic-friendly concentrations of 10−10–10−5 M by suppressing the mitotic activity of the neoblasts. This hormone does not affect the posterior end’s regeneration; thus, its regeneration effect is significantly elective.
References
Anisimov, V.N., Popovich, I.G., Shtylik, A.V., et al., Melatonin and Colon Carcinogenesis. III. Effect of Melatonin on Proliferative Activity and Apoptosis in Colon Mucosa and Colon Tumors Induced by 1,2-Dimethylhydrazine in Rats, Exp. Toxicol. Pathol., 2000, vol. 52, pp. 71–76.
Cos, S., Blask, D.E., Lemus-Wilson, A., et al., Effects of Melatonin on the Cell Cycle Kinetics and “Estrogen-Rescue” of MCF-7 Human Breast Cancer Cells in Culture, J. Pineal Res., 1991, vol. 10, pp. 36–42.
Hardeland, R. and Poeggeler, B., Non-Vertebrate Melatonin, J. Pineal Res., 2003, vol. 34, pp. 233–241.
Morita, M., Hall, F., Best, J.B., et al., Photoperiodic Modulation of Cephalic Melatonin in Planarians, J. Exp. Zool., 1987, vol. 214, pp. 383–388.
Sanchez Alvarado, A., Newmark, P.A., Robb, S.M., et al., The Schmidtea Mediterranea Database as a Molecular Resource for Studying Platyhelminthes, Stem Cells and Regeneration, Development, 2002, vol. 129, pp. 5659–5665.
Sheiman, I.M., Tiras, Kh.P., and Balobanova, E.F., The Morphogenetic Functions of Neuropeptides, in Fiziol. Zh. SSSR im. I.M. Sechenova, 1989, vol. 75,issue 5, pp. 619–626.
Tiras, Kh.P., Rubina, A.Yu., Miloserdov, Yu.V., et al., A Morphogen of Hydra as a Possible Endogenous Stimulator of Regeneration of Planarians, in Morfogeneticheski aktivnye veshchestva (Morphogenetically Active Substances), Pushchino: Pushch. Nauch. Tsents Akad. Nauk SSSR, 1989, pp. 134–145.
Tiras, Kh.P., Srebnitskaya, L.K., Il’yasova, E.N., et al., Effect of Weak Combined Magnetic Field on the Regeneration Rate of the Planarian Dugesia tigrina, Biofizika, 1996, vol. 40, no. 4, pp. 826–831.
Yoshizawa, Y., Wakabayashi, K., and Shinozawa, T., Inhibition of Planarian Regeneration by Melatonin, Hydrobiologia, 1991, vol. 227, pp. 31–40.
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Original Russian Text © O.N. Yermakova, A.M. Yermakov, Kh.P. Tiras, V.V. Lednev, 2009, published in Ontogenez, 2009, Vol. 40, No. 6, pp. 466–469.
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Yermakova, O.N., Yermakov, A.M., Tiras, K.P. et al. Melatonin effect on the regeneration of the flatworm Girardia tigrina . Russ J Dev Biol 40, 382–385 (2009). https://doi.org/10.1134/S1062360409060083
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DOI: https://doi.org/10.1134/S1062360409060083