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Analysis of sensitivity of stromal stem cells (CFU-f) from rat bone marrow and fetal liver to 5-fluorouracil

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Abstract

The sensitivity of stromal stem cells (CFU-f) from rat bone marrow and fetal liver to the cytotoxic effect of 5-fluorouracil (5-FU) was compared in vivo and in vitro. Cells from both tissues demonstrated a similar resistance to 5-FU in vitro; however, stromal stem cells from fetal liver proved notably more sensitive to 5-FU compared to marrow CFU-f in vivo. Cells forming colonies of different size were identified in stem cell populations from both tissues. Cells giving rise to small colonies had a higher resistance to 5-FU both in vivo and in vitro.

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Authors and Affiliations

  1. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119991, Russia

    O. V. Payushina, E. I. Domaratskaya, E. I. Bueverova, T. M. Nikonova, N. N. Butorina, E. A. Molchanova & V. I. Starostin

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  1. O. V. Payushina
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  2. E. I. Domaratskaya
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  3. E. I. Bueverova
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  4. T. M. Nikonova
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  5. N. N. Butorina
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  6. E. A. Molchanova
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  7. V. I. Starostin
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Original Russian Text ©O.V. Payushina, E.I. Domaratskaya, E.I. Bueverova, T.M. Nikonova, N.N. Butorina, E.A. Molchanova, V.I. Starostin, 2006, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2006, No. 6, pp. 660–666.

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Payushina, O.V., Domaratskaya, E.I., Bueverova, E.I. et al. Analysis of sensitivity of stromal stem cells (CFU-f) from rat bone marrow and fetal liver to 5-fluorouracil. Biol Bull Russ Acad Sci 33, 536–541 (2006). https://doi.org/10.1134/S1062359006060021

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  • DOI: https://doi.org/10.1134/S1062359006060021

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