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Enhanced Non-Enzymatic Glucose Detection Using a Flower-Like NiCo2O4 Spheres Modified Electrode

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Abstract

The development of non-enzymatic glucose detection method is of great significance in the clinical, biological and food sample analysis. In this work, a NiCo2O4-Nafion modified glassy carbon electrode was successfully fabricated which can rapidly detect glucose (<5 s) with high selectivity. Flower-like nanorod-shaped NiCo2O4 spheres were simply synthesized via an one-pot hydrothermal reaction which were characterized by scanning electron microscope and X-ray diffraction. The as-prepared NiCo2O4 and Nafion modified glassy carbon electrode showed remarkable electrochemical activity for glucose detection in both cyclic voltammetry and chronoamperometry measurements. The anodic current was linearly proportional to glucose concentration in a broad range from 0.1 to 1360 μM. The detection limit of our NiCo2O4−Nafion modified electrode was determined as 10 nM (S/N = 3). Finally, the modified electrode exhibited high stability, selectivity and reproducibility. The electrode has been successfully applied to detect glucose in real food samples.

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Funding

This work was financially supported by the Natural Science Foundation of China (nos. 51508172, 51572076 and 51378183), Project for Discipline Groups Construction of Food New-type Industrialization and the Students’ Scientific Research Funds of Hubei University of Arts and Science, and Hainan University.

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Authors and Affiliations

  1. School of Food Science and Technology and School of Chemical Engineering, Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices, Hubei University of Arts and Science, 441053, Xiangyang, China

    Suqin Liu, Li Liu, Wanqiang Wang & Gaopeng Dai

  2. Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education and School of Chemical Engineering and Technology, Hainan University, 570228, Haikou, Hainan, China

    Yang Zhou & Yuanyuan Liu

Authors
  1. Suqin Liu
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  2. Li Liu
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  3. Wanqiang Wang
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  4. Yang Zhou
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  5. Gaopeng Dai
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  6. Yuanyuan Liu
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Correspondence to Gaopeng Dai or Yuanyuan Liu.

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Liu, S., Liu, L., Wang, W. et al. Enhanced Non-Enzymatic Glucose Detection Using a Flower-Like NiCo2O4 Spheres Modified Electrode. J Anal Chem 76, 993–1001 (2021). https://doi.org/10.1134/S1061934821080098

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  • DOI: https://doi.org/10.1134/S1061934821080098

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