Abstract
Titrimetric and spectrophotometric assay of pantoprazole sodium sesquihydrate (PSS) using cerium(IV) sulphate as the oxidimetric reagent is described. The methods are based on the oxidation of PSS with a measured excess of Ce(IV) sulphate followed by the determination of unreacted oxidant using different reaction schemes. In titrimetry, the unreacted oxidant was determined by back titration with ferrous ammonium sulphate (FAS) in sulphuric acid medium. Spectrophotometry involves the reduction of unreacted Ce(IV) sulphate with a fixed quantity of Fe(II). The resulting Fe(III) is complexed with thiocyanate and the absorbance is measured at 470 nm. In both the methods, the amount of Ce(lV) sulphate reacted corresponds to PSS concentration. Titrimetry is applicable over 1–10 mg range whereas in spectrophotometry, the calibration graph is linear in the range of 0.5–7.0 μg/mL and the calculated molar absorptivity value is 1.58 × 105 L/mol cm. The validity of the proposed methods was tested by analyzing pure and dosage forms containing PSS. Statistical treatment of the results reflects that the proposed procedures are precise, accurate and easily applicable to the determination of PSS in pure form and in pharmaceutical formulations.
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References
Burger’s Medicinal Chemistry and Drug Discovery, vol. 2: Therapeutic Agents, Wolff, M.E., Ed., New York: Wiley, 1996, 5th ed., ch. 27.
The Merck Index, Budavari, S., Ed., New Jersey, 1996, 12th ed., p. 1205.
Mansour, A.M. and Sorour, O.M., Chromatographia, 2001, vol. 53, p. 478.
Patel, B.H., Suhagia, B.N., Patel, M.M., and Patel, J.R., Chromatographia, 2007, vol. 65, p. 743.
Xue-Hui, H. and Fu-Sheng, P., Zhongguo Yiyao Gongye Zazhi, 2000, vol. 31, p. 502.
Basavaiah, K., Anilkumar, U.R., and Tharpa, K., Int. J. Chem. Sci., 2008, vol. 6, p. 579.
Agbaba, D., Novovic, D., Karljikovic-Rajic, K., and Marinkovic, V.J., J. Planar Chromatogr.-Mod. TLC, 2004, vol. 17, p. 169.
Karljikovic-Rajic, K., Novovic, D., Marinkovic, D., and Agbaba, D., J. Pharm. Biomed. Anal., 2003, vol. 32, p. 1019.
Wahbi, A.M., Abdel-Razak, O., Gazy, A.A., Mahgoub, H., and Moneeb, M.S., J. Pharm. Biomed. Anal., 2002, vol. 30, p. 1133.
Salama, F., El-Abasawy, N., Razeq, S.A.A., Ismail, M.F., and Fouad, M.M., J. Pharm. Biomed. Anal., 2003, vol. 33, p. 411.
Moustafa, A.A.M., J. Pharm. Biomed. Anal., 2000, vol. 22, p. 45.
Rahman, N. and Kashif, M., Pharmazie, 2000, vol. 60, p. 197.
Basavaiah, K. and Anilkumar, U.R., Indian J. Chem. Tehnol., 2007, vol. 14, p. 611.
Basavaiah, K. and Anilkumar, U.R., Bulg. Chem. Commun., 2007, vol. 39, p. 159.
Rahman, N., Bano, Z., and Azmi, S.N.H., Anal. Sci., 2006, vol. 22, p. 983.
Int. Conf. on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, ICH Harmonised Tripartite Guideline Validation of Analytical Procedures: Text and Methodology Q2(R 1), London, 2005.
Basset, J., Denney, R.C., Jeffery, G.H., and Mendham, J., in Vogel’s Textbook of Quantitative Inorganic Analysis, London: Longman, 1978, p. 360.
March, J., in March’s Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, Singapore: Wiley, 2004, p. 1201.
Trost, B.M. and Curran, D.P., Tetrahedron Lett., 1980, vol. 21, p. 1287.
Ashworth, M.R.F., Titrimetric Organic Analysis, New York: Wiley, 1964, pt 1.
Kolthoff, I.M. and Belcher, R., Volumetric Analysis, New York: Interscience, 1957, vol. 3.
Berka, A., Vulterin, J., and Zyka, J., Newer Redox Titrants, London: Pergamon, 1965.
Basavaiah, K., Chandrashekar, U., and Prameela, H.C., Turk. J. Chem., 2003, vol. 27, p. 591.
Sandell, E., Colorimetric Determination of Traces of Metals, New York: Interscience, 1959.
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Devi, O.Z., Basavaiah, K., Revanasiddappa, H.D. et al. Titrimetric and spectrophotometric assay of pantoprazole in pharmaceuticals using cerium(IV) sulphate as oxidimetric agent. J Anal Chem 66, 490–495 (2011). https://doi.org/10.1134/S1061934811050133
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DOI: https://doi.org/10.1134/S1061934811050133