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Elastogenesis-related gene polymorphisms and the risk of pelvic organ prolapse development

  • Human Genetics
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Abstract

Pelvic organ prolapse (POP) represents a urologic and gynecological disease, the development of which is governed both by environmental and genetic factors. We describe the results of our association study of polymorphic variants of genes involved in the assembly of elastic fibrils, namely, the lysyl oxidase-like protein 1 (LOXL1) and fibulin-3 (FBLN3) genes. We revealed an association of the rs2304719-T allele and rs2165241(C)–rs2304719(T)–rs893821(T) haplotype of the LOXL1 gene with an increased risk of POP development, as well as a weak association with the disease of the rs3791660-C allele and the rs3791679(T)–rs1367228(A)–rs3791660(C)–rs2033316(A) haplotype of the FBLN3 gene.

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Authors and Affiliations

  1. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia

    M. B. Khadzhiev, S. K. Abilev & L. E. Salnikova

  2. Pirogov Russian National Research Medical University, Moscow, 117997, Russia

    S. V. Kamoeva & A. V. Ivanova

  3. Moscow State University, Moscow, 119991, Russia

    S. K. Abilev

Authors
  1. M. B. Khadzhiev
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  2. S. V. Kamoeva
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  3. A. V. Ivanova
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  4. S. K. Abilev
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  5. L. E. Salnikova
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Correspondence to M. B. Khadzhiev.

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Original Russian Text © M.B. Khadzhieva, S.V. Kamoeva, A.V. Ivanova, S.K. Abilev, L.E. Salnikova, 2015, published in Genetika, 2015, Vol. 51, No. 10, pp. 1191–1198.

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Khadzhiev, M.B., Kamoeva, S.V., Ivanova, A.V. et al. Elastogenesis-related gene polymorphisms and the risk of pelvic organ prolapse development. Russ J Genet 51, 1026–1032 (2015). https://doi.org/10.1134/S1022795415100087

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  • DOI: https://doi.org/10.1134/S1022795415100087

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