Abstract
The variability of eight polymorphic variants of the IL4, IL4R, IL10, IL13, IL12A, and IL12RB2 genes encoding key cytokines and their receptors in 57 world populations has been assessed. A correlation between the allele frequency distribution of the examined genes and climatic and geographic factors was observed.
References
Vojvodić, S. and Ademović-Sazdanić, D., Study of the HLA class II allele polymorphism and phylogenetic analysis in Vojvodina population, Russ. J. Genet., 2011, vol. 47, no. 3, pp. 364–368.
Freidin, M.B. and Puzyrev, V.P., Syntropic genes of allergic diseases, Russ. J. Genet., 2010, vol. 46, no. 2, pp. 224–229.
Hancock, A.M., Witonsky, D.B., Gordon, A.S., et al., Adaptations to climate in candidate genes for common metabolic disorders, PLoS Genet., 2008, vol. 4, no. 2. e32
Stepanov, V.A., Kandelariya, P., Kkho, S., et al., Decanalization of immune response during the resettlement of modern man: the relationship of genetic diversity among the genes encoding immune response with the climatic and geographical factors, Med. Genet., 2013, no. 4, pp. 8–18.
Bottema, R.W., Nolte, I.M., Howard, T.D., et al., Interleukin 13 and interleukin 4 receptor-α polymorphisms in rhinitis and asthma, Int. Arch. Allergy Immunol., 2010, vol. 153, no. 3, pp. 259–267.
Bottema, R.W., Reijmerink, N.E., Kerkhof, M., et al., Interleukin 13, CD14, pet and tobacco smoke influence atopy in three Dutch cohorts: the allergenic study, Eur. Respir. J., 2008, vol. 32, no. 3, pp. 593–602.
Granada, M., Wilk, J.B., Tuzova, M., et al., A genomewide association study of plasma total IgE concentrations in the Framingham Heart Study, J. Allergy Clin. Immunol., 2012, vol. 129, no. 3, pp. 840–845.
Gaddam, S.L., Priya, V.H., Babu, B.M., et al., Association of interleukin-10 gene promoter polymorphism in allergic patients, Genet. Test. Mol. Biomarkers, 2012, vol. 16, no. 6, pp. 632–635.
Hyun, M.H., Lee, C.H., Kang, M.H., et al., Interleukin-10 promoter gene polymorphisms and susceptibility to asthma: a meta-analysis, PLoS One, 2013, vol. 8, no. 1. e53758
Mells, G.F., Floyd, J.A., Morley, K.I., et al., Genomewide association study identifies 12 new susceptibility loci for primary biliary cirrhosis, Nat. Genet., 2011, vol. 43, no. 4, pp. 329–332.
Hirschfield, G.M., Liu, X., Xu, C., et al., Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants, N. Engl. J. Med., 2009, vol. 360, no. 24, pp. 2544–2555.
Liu, X., Invernizzi, P., Lu, Y., et al., Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis, Nat. Genet., 2010, vol. 42, no. 8, pp. 658–660.
Apter, A.J., Schelleman, H., Walker, A., et al., Clinical and genetic risk factors of self-reported penicillin allergy, J. Allergy Clin. Immunol., 2008, vol. 122, no. 1, pp. 152–158.
Movahedi, M., Amirzargar, A.A., Nasiri, R., et al., Gene polymorphisms of interleukin-4 in allergic rhinitis and its association with clinical phenotypes, Am. J. Otolaryngol., 2013, vol. 34, no. 6, pp. 676–681.
Yang, X.X., Li, F.X., Wu, Y.S., et al., Association of TGF-beta1, IL-4 and IL-13 gene polymorphisms with asthma in a Chinese population, Asian Pac. J. Allergy Immunol., 2011, vol. 29, no. 3, pp. 273–277.
Howard, T.D., Koppelman, G.H., Xu, J., et al., Genegene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma, Am. J. Hum. Genet., 2002, vol. 70, no. 1, pp. 230–236.
Stepanov, V.A. and Trifonova, E.A., Multiplex SNP genotyping by MALDI-TOF mass spectrometry: frequencies of 56 immune response gene SNPs in human populations, Mol. Biol., 2013, vol. 47, no. 6, pp. 852–862.
Stepanov, V.A., Trifonova, E.A., Simonova, K.V., et al., Variability in genes of interleukin 4 and its receptor in the indigenous populations of Siberia, Med. Genet., 2013, no. 4, pp. 38–40.
Frazer, K.A., Ballinger, D.G., Cox, D.R., et al., A second generation human haplotype map of over 3.1 million SNPs, Nature, 2007, vol. 449, no. 7164, pp. 851–861.
Abecasis, G.R., Altshuler, D., Auton, A., et al., A map of human genome variation from population-scale sequencing, Nature, 2010, vol. 467, no. 7319, pp. 1061–1073.
Cann, H.M., de Toma, C., Cazes, L., et al., A human genome diversity cell line panel, Science, 2002, vol. 296, no. 5566, pp. 261–262.
Excoffier, L., Laval, G., and Schneider, S., Arlequin ver. 3.0: an integrated software package for population genetics data analysis, Evol. Bioinform. Online, 2005, vol. 1, pp. 47–50.
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Original Russian Text © A.A. Cherednichenko, E.A. Trifonova, K.V. Vagaitseva, A.V. Bocharova, V.A. Stepanov, 2014, published in Genetika, 2014, Vol. 50, No. 10, pp. 1254–1258.
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Cherednichenko, A.A., Trifonova, E.A., Vagaitseva, K.V. et al. Association of the genenetic polymorphism of cytokines and their receptors with climate and geographic factors in human populations. Russ J Genet 50, 1112–1116 (2014). https://doi.org/10.1134/S1022795414100020
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DOI: https://doi.org/10.1134/S1022795414100020