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Conditional lethal mutations shift the genome from stability to instability

  • Molecular Genetics
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Abstract

The phenomenology of genomic destabilization is described in Drosophila melanogaster mutants containing radiation-induced conditional dominant lethals in the X chromosome and in autosome 2. Destabilization manifests itself as (1) the loss or decrease of lethality of previously lethal mutations; (2) the loss of expression of visible dominant mutations in an opposite homolog; (3) chromosomal instability resulting in the loss of the X chromosome in germline and somatic cells; (4) the occurrence of novel mutations (secondary mutagenesis); (5) the occurrence of single and mass modifications; (6) disturbances in individual development (formation of morphoses). The key event for the shift of the genome from the stable state into the unstable one is the occurrence of a conditional dominant lethal mutation.

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090, Russia

    B. F. Chadov, E. V. Chadova, E. A. Khotskina & N. B. Federova

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  1. B. F. Chadov
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  2. E. V. Chadova
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  3. E. A. Khotskina
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  4. N. B. Federova
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Correspondence to B. F. Chadov.

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Original Russian Text © B.F. Chadov, E.V. Chadova, E.A. Khotskina, N.B. Federova, 2009, published in Genetika, 2009, Vol. 45, No. 3, pp. 318–329.

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Chadov, B.F., Chadova, E.V., Khotskina, E.A. et al. Conditional lethal mutations shift the genome from stability to instability. Russ J Genet 45, 276–286 (2009). https://doi.org/10.1134/S102279540903003X

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  • DOI: https://doi.org/10.1134/S102279540903003X

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