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Water-soluble nonstoichiometric polyelectrolyte complexes of modified chitosan

  • Polyelectrolytes
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Abstract

A modified polysaccharide that, in each deacetylated unit, carries a functional secondary amino group and a quaternized amino group that provides a positive charge and solubility to the polymer throughout the pH range is prepared by the alkylation of primary amino groups of chitosan with glycidyltrimethylammonium chloride. The mixing of modified chitosan solutions with solutions of polystyrenesulfonate or polymethacrylate anions in neutral solutions gives rise to negatively charged nonstoichiometric polyelectrolyte complexes soluble and stable under physiological conditions. The effects of pH, ionic strength, the degree of polymerization, the nature of the lyophilizing polyanion, and the charge-to-charge ratio of components on the boundaries of existence of soluble complexes are ascertained. The collected experimental data may serve as a basis for designing biocompatible and biodegradable means useful for the delivery of genetic material and drugs to living cells.

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Authors and Affiliations

  1. Faculty of Chemistry, Moscow State University, Moscow, 119991, Russia

    V. A. Izumrudov

  2. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Leninskii pr. 29, Moscow, 119991, Russia

    I. F. Volkova, E. S. Grigoryan & M. Yu. Gorshkova

Authors
  1. V. A. Izumrudov
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  2. I. F. Volkova
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  3. E. S. Grigoryan
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  4. M. Yu. Gorshkova
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Corresponding author

Correspondence to V. A. Izumrudov.

Additional information

Original Russian Text © V.A. Izumrudov, I.F. Volkova, E.S. Grigoryan, M.Yu. Gorshkova, 2011, published in Vysokomolekulyarnye Soedineniya, Ser. A, 2011, Vol. 53, No. 4, pp. 515–524.

This work was supported by the Russian Foundation for Basic Research, project no. 10-03-00019-a.

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Izumrudov, V.A., Volkova, I.F., Grigoryan, E.S. et al. Water-soluble nonstoichiometric polyelectrolyte complexes of modified chitosan. Polym. Sci. Ser. A 53, 281–288 (2011). https://doi.org/10.1134/S0965545X11040043

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  • DOI: https://doi.org/10.1134/S0965545X11040043

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