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Micro-RNA in Patients with Carotid Atherosclerosis

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Abstract

Atherosclerosis is a multifactorial disease and one of the leading causes of ischaemic stroke. In recent years, microRNA has become an important factor to consider in the pathogenesis of atherosclerosis. MicroRNAs are non-coding RNA sequences that are divided into proatherogenic and atheroprotective. This study evaluated the leukocyte expression of certain microRNAs (miR-126-(5p/3p), miR-29a-(5p/3p), miR-33a-5p and miR-21-(5p/3p)) in patients with carotid atherosclerosis. Statistically significant differences were found between patient groups in regard to the molecular levels, as well as correlations between several microRNAs. This indicates the potential use of microRNA in diagnosis and treatment, and confirms the role of microRNAs as important regulators of carotid atherosclerosis.

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Authors and Affiliations

  1. Research Center of Neurology, Moscow, Russia

    A. A. Raskurazhev, M. M. Tanashyan, A. A. Shabalina, P. I. Kuznetsova, A. A. Kornilova & A. G. Burmak

Authors
  1. A. A. Raskurazhev
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  2. M. M. Tanashyan
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  3. A. A. Shabalina
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  4. P. I. Kuznetsova
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  5. A. A. Kornilova
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  6. A. G. Burmak
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Corresponding author

Correspondence to A. A. Raskurazhev.

Ethics declarations

COMPLIANCE WITH ETHICAL STANDARDS

The study was conducted in accordance with the ethical standards set out in the Declaration of Helsinki 1964 and its subsequent revisions, and approved by the Local Ethics Committee (Minutes of meeting no. 11-4/19 dated 20/11/19); all patients provided written voluntary informed consent.

AUTHOR CONTRIBUTIONSRaskurazhev A.A.—grant executor, study initiator, concept, plan and methodology development, statistical processing, writing the initial version of the manuscript.Tanashyan M.M.—creating the research concept, monitoring the execution, final review of the manuscript.Shabalina A.A.—preparing the laboratory protocol for microRNA study, performing the tests, statistical data processing.Kuznetsova P.I.—patient recruitment for the study.Kornilova A.A.—grant co-executor, patient recruitment for the study, database management, manuscript preparation.Burmak A.G.—performing laboratory tests, taking blood samples for the study.

FINANCING

Grant no. МК-3978.2019.7 of the President of the Russian Federation (Ministry of Science and Higher Education of the Russian Federation).

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Raskurazhev, A.A., Tanashyan, M.M., Shabalina, A.A. et al. Micro-RNA in Patients with Carotid Atherosclerosis. Hum Physiol 46, 880–885 (2020). https://doi.org/10.1134/S0362119720080113

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