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Search for associations between G/A polymorphism of the EPAS1 gene and the maximal oxygen consumption in Russian athletes

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Abstract

This study investigates associations between G/A polymorphism of the epithelial PAS domain protein 1 (EPAS1) gene (rs1867785) and the maximum rate of oxygen consumption (VO2max) in male Russian athletes. The study engaged 241 male athletes from different sports; the control group of nonathletes included 92 subjects. Increased frequencies of the AA and AG genotypes of the EPAS1 gene (χ2 = 14.16, p = 0.03) were found in the cohort of male athletes. The frequencies of these alleles in the subgroups with moderate (EPAS1*A 38.1% and EPAS1*G 61.9%) and high (EPAS1*A 41.8% and EPAS1*G 58.2%) VO2max values significantly differed from those in the control group (χ2 = 7.53, p = 0.006 and χ2 = 6.58, p = 0.01, respectively). The higher aerobic capacities are probably associated with the presence of at least one minor A allele of the EPAS1 gene in the genome.

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Authors and Affiliations

  1. Research Institute and Museum of Anthropology, Moscow State University, Moscow, Russia

    E. A. Bondareva, A. N. Bleer & E. Z. Godina

  2. Russian State University of Physical Education, Sport, Youth, and Tourism, Moscow, Russia

    E. Z. Godina

Authors
  1. E. A. Bondareva
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  2. A. N. Bleer
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  3. E. Z. Godina
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Correspondence to E. A. Bondareva.

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Original Russian Text © E.A. Bondareva, A.N. Bleer, E.Z. Godina, 2016, published in Fiziologiya Cheloveka, 2016, Vol. 42, No. 3, pp. 120–124.

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Bondareva, E.A., Bleer, A.N. & Godina, E.Z. Search for associations between G/A polymorphism of the EPAS1 gene and the maximal oxygen consumption in Russian athletes. Hum Physiol 42, 335–338 (2016). https://doi.org/10.1134/S0362119716010047

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  • DOI: https://doi.org/10.1134/S0362119716010047

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