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Functional status of microcirculatory-tissue systems during the cold pressor test

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Abstract

The time course of changes in the parameters of microcirculatory–tissue systems (MTSs) during the cold pressor test (CPT) was investigated in 32 conventionally healthy volunteers by noninvasive optical methods of laser Doppler flowmetry (LDF), tissue reflectance oximetry (TRO), and pulse oximetry. Depending on the oxygen consumption recovery rate in the CPT, the subjects were conventionally divided into two groups, one with a normal physiology and the other with a tendency to vascular spasm and lack of functional recovery of the MTSs. Blood flow oscillations were analyzed in detail to identify the possible causes of vascular spasm. The causes might include a distortion of the tone-shaping myogenic mechanisms that regulate resistive microvessels, blood congestion in microcirculation, or a combination of both of the factors. The CPT used to assess the MTS function was assumed to report the MTS reserve and to detect a propensity for vascular spasm at a preclinical stage, thus being of a potential applied significance.

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References

  1. Krupatkin, A.I., Noninvasive estimation of human tissue respiration with wavelet-analysis of oxygen saturation and blood flow oscillations in skin microvessels, Hum. Phys., 2012, vol. 38, no. 4, p. 396.

    Article  CAS  Google Scholar 

  2. Tuchin, V.V., Opticheskaya biomeditsinskaya diagnostika (Optical Biomedical Diagnosis), in 2 volumes, Moscow: Fizmatlit, 2007.

    Google Scholar 

  3. Krupatkin, A.I. and Sidorov, V.V., Funktsional’naya diagnostika sostoyaniya mikrotsirkulyatorno-tkanevykh sistem: kolebaniya, informatsiya, nelineinost'. Rukovodstvo dlya vrachei (Functional Diagnosis of the State of Microcirculatory–Tissue Systems: Oscillations, Information, Nonlinearity. A Guidebook for Physicians), Moscow: Knizhnyi dom “LIBROKOM”, 2013.

    Google Scholar 

  4. Primenenie lazernoi dopplerovskoi floumetrii v meditsinskoi praktike: Mater. III Vserossiiskogo simpoziuma (Use of Laser Doppler Flowmetry in Medicine: Proc. III All-Russia Conf.), Kozlov, V.I., Ed., Moscow, 2000.

  5. Rogatkin, D.A., Physical basis of reflectance oximetry, Med. Fiz., 2012, no. 2, p. 97.

    Google Scholar 

  6. Shurygin, I.A., Monitoring dykhaniya: pul’soksimetriya, kapnografiya, oksimetriya (Monitoring Respiration: Pulse Oximetry, Capnography, Oximetry), St. Petersburg: Nevskii Dialekt, 2000.

    Google Scholar 

  7. Materialy IV Vserossiiskoi nauchnoi konferentsii s mezhdunarodnym uchastiem “Mikrotsirkulyatsiya v klinicheskoi praktike”: Angiologiya i sosudistaya khirurgiya (Proc. IV All-Russia Conf. with International Participation “Micricirculation in Medicine”: Angiology and Vascular Surgery), 2012, vol. 18, suppl. C.

  8. Usanov, D.A., Skripal’, A.V., and Protopopov, A.A., Evaluation of the functional state of blood vessels by analyzing the temperature response to the occlusion test, Saratov. Nauchno-Med. Zh., 2009, vol. 5, no. 4, p. 554.

    Google Scholar 

  9. Stankevich, A.V., Akhapkina, A.A., and Tikhomirova, I.A., Functional tests in evaluating the functional reserves of circulation in athletes, Yaroslav. Pedagog. Vestn., 2013, vol. 3, no. 4, p. 190.

    Google Scholar 

  10. Azizov, G.A., Functional tests in estimating the severity of microcirculation defects in leg vascular disorders, Region. Krovoobr. Mikrotsirkulyats., 2006, no. 1 (17), p. 37.

    Google Scholar 

  11. Prokof’eva, T.V., Yatsenko, M.K., Voronina, L.P., and Polunina, E.A., Heat test in patients with class III stable angina of effort during inpatient treatment with LDF testing, Fu’damental’n. Issled., 2007, no. 12, p. 91.

    Google Scholar 

  12. Piskunova, G.M., Chemeris, N.K., Krasnikov, G.V., et al., Heat test with a linear increase in heating temperature in studying te mechanisms regulating the microcirculation system of the human skin, Vestn. Nov. Med. Tekhnol., 2002, no. 4, p. 89.

    Google Scholar 

  13. Minkley, N., Schröde, T.P., Wolf, O.T., and Kirchner, W.H., The socially evaluated cold-pressor test (SECPT) for groups: Effects of repeated administration of a combined physiological and psychological stressor, Psychoneuroendocrinology, 2014, vol. 45, p. 119.

    Article  PubMed  Google Scholar 

  14. Stefanovska, A., Bracic, M., and Kvernmo, H.D., Wavelet analysis of oscillations in the peripheral blood circulation measured by laser Doppler technique, IEEE Trans. Biomed. Eng., 1999, vol. 46, no. 10, p. 1230.

    Article  CAS  PubMed  Google Scholar 

  15. Tankanag, A. and Chemeris, N., Application of the adaptive wavelet transform for analysis of blood flow oscillations in the human skin, Phys. Med. Biol., 2008, vol. 53, no. 21, p. 5967.

    Article  PubMed  Google Scholar 

  16. Dunaev, A.V., Sidorov, V.V., Krupatkin, A.I., et al., Investigating tissue respiration and skin microhaemocirculation under adaptive changes and the synchronization of blood flow and oxygen saturation rhythms, Physiol. Measurement, 2014, vol. 35, no. 4, p. 607.

    Article  CAS  Google Scholar 

  17. Yunkerov, V.I. and Grigor’ev, S.G., Matematiko-statisticheskaya obrabotka dannykh meditsinskikh issledovanii (Mathematical Statistical Processing of Data from Medical Studies), St. Petersburg: VMedA, 2002.

    Google Scholar 

  18. Velasco, M., Gomez, J., Blanco, M., and Rodriguez, I., The cold pressor test: Pharmacological and therapeutic aspects, Am. J. Therapeutics, 1997, vol. 4 (1), p. 34.

    Article  CAS  Google Scholar 

  19. Zvezdin, M.S. and Achkasova, V.V., Response of skin vessels to distant cold exposure, Region. Krovoobr. Mikrotsirkulyats., 2006, vol. 5, no. 3 (19), p. 63.

    Google Scholar 

  20. Hall, J.E., Hall Guyton and Hall Textbook of Medical Physiology, 12th ed., Sauders, 2010.

    Google Scholar 

  21. Krupatkin, A.I., Cardiac and respiratory oscillations of the blood flow in microvessels of the human skin, Hum. Phys., 2008, vol. 34, no. 3, p. 323.

    Article  Google Scholar 

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Authors and Affiliations

  1. State University—Education-Science-Production Complex, Oryol, Russia

    I. N. Novikova & A. V. Dunaev

  2. LAZMA Research and Production Company, Moscow, Russia

    V. V. Sidorov

  3. Priorov Central Research Institute of Traumatology and Orthopedics, Moscow, Russia

    A. I. Krupatkin

Authors
  1. I. N. Novikova
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  2. A. V. Dunaev
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  3. V. V. Sidorov
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  4. A. I. Krupatkin
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Corresponding author

Correspondence to A. I. Krupatkin.

Additional information

Original Russian Text © I.N. Novikova, A.V. Dunaev, V.V. Sidorov, A.I. Krupatkin, 2015, published in Fiziologiya Cheloveka, 2015, Vol. 41, No. 6, pp. 95–103.

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Novikova, I.N., Dunaev, A.V., Sidorov, V.V. et al. Functional status of microcirculatory-tissue systems during the cold pressor test. Hum Physiol 41, 652–658 (2015). https://doi.org/10.1134/S0362119715060067

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  • DOI: https://doi.org/10.1134/S0362119715060067

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