Abstract
In this article, the characteristics of the functional activity of the anterior cingulate cortex (ACC), a key element of the neuroanatomical error detection system of the brain in drug-resistant forms of obsessive-compulsive disorder (OCD) are discussed on the basis of both original and published data. Available data indicate the presence of a functional deficit zone in the ACC during PCD. This fact suggests that the functions of the ACC in OCD patients are partially redistributed between other brain areas. Thus, in contrast to the previously accepted ideas, the target of stereotactic surgery for OCD is a pathologically altered brain region. Probably, this explains the fact that the operation does not lead to significant changes in the patient’s psyche. The pathological reorganization of the functional activity of the brain in OCD remains unclear and requires further investigation.
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Weismann, M.M., Bland, R.C., Canino, G.J., et al., The Cross-National Epidemiology of Obsessive-Compulsive Disorder, J. Clin. Psychiatry, 1994, vol. 55, p. 5.
Bystritsky, A., Current Pharmacological Treatments for Obsessive-Compulsive Disorder, Essen. Psychopharmacol., 2004, vol. 5, p. 251.
Brandl, E., Müller, D., and Richter, M., Pharmacogenetics of Obsessive-Compulsive Disorders, Pharmacogenomics, 2012, vol. 13, p. 71.
Medvedev, S.V., Anichkov, A.D, and Polyakov, Yu.I., Physiological Mechanisms of the Effectiveness of Bilateral Stereotactic Cingulotomy against Strong Psychological Dependence in Drug Addicts, Hum. Physiol., 2003, vol. 29, no. 4, p. 117.
Bechtereva, N.P. and Gretchin, V.B., Physiological Foundations of Mental Activity, Int. Rev. Neurobiol., 1968, vol. 11, p. 329.
Weston, C.S., Another Major Function of the Anterior Cingulate Cortex: the Representation of Requirements, Neurosci. Biobehav. Rev., 2012, vol. 36, p. 90.
Etkin, A., Egner, T., and Kalisch, R., Emotional Processing in Anterior Cingulate and Medial Prefrontal Cortex, Trends. Cogn. Sci., 2011, vol. 15, p. 85.
Apps, M.A., Balsters, J.H., and Ramnani, N., The Anterior Cingulate Cortex: Monitoring the Outcomes of Others’ Decisions, Soc. Neurosci., 2012, vol. 4, p. 424.
Kim, C.H., Chang, J.W., Koo, M.S., et al., Anterior Cingulotomy for Refractory Obsessive-Compulsive Disorder, Acta Psychiatr. Scand., 2003, vol. 107, p. 283.
Lopes, A., de Mathis, M., Canteras, M., et al., Update on Neurosurgical Treatment for Obsessive Compulsive Disorder, Rev. Bras. Psiquiatr., 2004, vol. 26, p. 61.
Jung, H.H., Kim, C.H., Chang, J.H., et al., Bilateral Anterior Cingulotomy for Refractory Obsessive-Compulsive Disorder: Long-Term Follow-Up Results, Stereotact. Funct. Neurosurg., 2006, vol. 84, p. 184.
Kireev, M.V., Korotkov, A.D., Polyakov, Yu.I., et al., The Brain Mechanism of Error Detection: The P.E.T. Study, Ross. Fiziol. Zh. im. I.M. Sechenova, 2011, vol. 97, p. 1060.
Genovese, C.R., Lazar, N., and Nichols, T., Thresholding of Statistical Maps in Functional Neuroimaging Using the False Discovery Rate, NeuroImage, 2002, vol. 15, p. 870.
Swedo, S.E., Schapiro, M.B., Grady, C.L., et al. Cerebral Glucose Metabolism in Childhood-Onset Obsessive-Compulsive Disorder, Arch. Gen. Psychiatry, 1989, vol. 46, p. 518.
Busatto, G.F., Zamignani, D.R., Buchpiguel, C., et al., A Voxel-Based Investigation of Regional Cerebral Blood Flow Abnormalities in Obsessive-Compulsive Disorder Using Single Photon Emission Computed Tomography (SPECT), Psychiatry Res., 2000, vol. 99, p. 15.
Ursu, S., Stenger, V.A., Shear, M.K., et al., Obsessive-Compulsive Disorder: Evidence from Functional Magnetic Resonance Imaging, Psychol. Sci., 2003, vol. 14, p. 347.
Fitzgerald, K.D., Welsh, R.C., Gehring, W.J., et al., Error-Related Hyperactivity of the Anterior Cingulate Cortex in Obsessive-Compulsive Disorder, Biol. Psychiatry, 2005, vol. 57, p. 287.
Maltby, N., Tolin, D.F., Worhunsky, P., et al., Dysfunctional Action Monitoring Hyperactivates Frontal-Striatal Circuits in Obsessive-Compulsive Disorder: An Event-Related fMRI Study, NeuroImage, 2005, vol. 24, p. 495.
Adler, C.M., Mc Donough-Ryan P., Sax, K.W., et al., fMRI of Neuronal Activation with Symptom Provocation in Unmedicated Patients with Obsessive Compulsive Disorder, J. Psychiatr. Res., 2000, vol. 34, p. 317.
Viard, A., Flament, M.F., Artiges, E., et al., Cognitive Control in Childhood-Onset Obsessive-Compulsive Disorder: A Functional MRI Study, Psychol. Med., 2005, vol. 35, p. 1007.
Remijnse, P.L., Nielen, M.M., van Balkom, A.J.L.M., et al., Reduced Orbitofrontal-Striatal Activity on a Reversal Learning Task in Obsessive-Compulsive Disorder, Arch. Gen. Psychiatry, 2006, vol. 63, p. 1225.
Roth, R.M., Saykin, A.J., Flashman, L., et al., Event-Related Functional Magnetic Resonance Imaging of Response Inhibition in Obsessive-Compulsive Disorder, Biol. Psychiatry, 2007, vol. 62, p. 901.
Ursu, S. and Carter, C.S., An Initial Investigation of the Orbitofrontal Cortex Hyperactivity in Obsessive-Compulsive Disorder: Exaggerated Representations of Anticipated Aversive Events?, Neuropsychologia, 2009, vol. 47, p. 2145.
Yücel, M., Harrison, B.J., Wood, S.J., et al., Functional and Biochemical Alterations of the Medial Frontal Cortex in Obsessive-Compulsive Disorder, Arch. Gen. Psychiatry, 2007, vol. 64, p. 946.
Page, L., Rubia, K., Deeley, Q., et al., A Functional Magnetic Resonance Imaging Study of Inhibitory Control in Obsessive-Compulsive Disorder, Psychiatry Res., 2009, vol. 174, p. 202.
Gu, B.M., Park, J.Y., Kang, D.H., et al., Neural Correlates of Cognitive Inflexibility during Task-Switching in Obsessive-Compulsive Disorder, Brain, 2008, vol. 131, p. 155.
Han, J., Kang, D., Gu, B., et al., Altered Brain Activation in Ventral Frontal-Striatal Regions Following a 16-Week Pharmacotherapy in Unmedicated Obsessive-Compulsive Disorder, J. Korean Med. Sci., 2011, vol. 26, p. 665.
Saxena, S. and Rauch, S.L., Functional Neuroimaging and the Neuroanatomy of Obsessive-Compulsive Disorder, Psychiatr. Clin. North. Am., 2000, vol. 23, p. 563.
Del Casale, A., Kotzalidis, G.D., Rapinesi, C., et al., Functional Neuroimaging in Obsessive-Compulsive Disorder, Neuropsychobiology, 2011, vol. 64, p. 61.
Whiteside, S.P., Port, J.D., and Abramowitz, J.S., A Meta-Analysis of Functional Neuroimaging in Obsessive-Compulsive Disorder, Psychiatry Res., 2004, vol. 132, p. 69.
Perani, D., Colombo, C., Bressi, S., et al., [18F]FDG PET Study in Obsessive-Compulsive Disorder. A Clinical/Metabolic Correlation Study after Treatment, Br. J. Psychiatry, 1995, vol. 166, p. 244.
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Original Russian Text © M.V. Kireev, N.S. Medvedeva, A.D. Korotkov, Ju.I. Polyakov, A.D. Anichkov, S.V. Medvedev, 2013, published in Fiziologiya Cheloveka, 2013, Vol. 39, No. 1, pp. 67–70.
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Kireev, M.V., Medvedeva, N.S., Korotkov, A.D. et al. Pathology of the anterior cingulate cortex in obsessive-compulsive disorder. Hum Physiol 39, 54–57 (2013). https://doi.org/10.1134/S0362119713010076
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DOI: https://doi.org/10.1134/S0362119713010076