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Effects of chorionic gonadotropin on peripheral monocytes vary with the phases of the menstrual cycle

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Abstract

The qualitative and quantitative effects of physiological concentrations of chorionic gonadotropin (CG) on monocytes of women vary with the phases of the menstrual cycle. During the follicular phase, the hormone inhibits phagocytosis; stimulates the secretion of interleukin (IL) 6 (IL-6), interferon α (IFN-α), and the protein component of apolipoprotein A1 (APO-A1); and activates myeloperoxidase (MPO). During the luteal phase, CG stimulates phagocytosis and APO-A1 secretion, inhibits MPO, and does not shift the levels of IL-6 and INF-α. Regardless of the menstrual phase, the hormone does not modify the release of elastase or the production of granulocytic colony-stimulating growth factor, IL-1α, and tumor necrosis factor α.

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References

  1. Hunt, J.S., Macrophages in Human Uteroplacental Tissues: A Review, Am. J. Reprod. Immunol., 1989, vol. 21, nos. 3–4, p. 119.

    PubMed  CAS  Google Scholar 

  2. Hunt, J.S. and Robertson, S.A., Uterine Macrophages and Environmental Programming for Pregnancy Success, J. Reprod. Immunol., 1996, vol. 32, no. 1, p. 1.

    Article  PubMed  CAS  Google Scholar 

  3. Kevorkov, N.N., Shilov, Yu.I., Shirshev, S.V., and Chereshnev, V.A., Gormony reproduktsii v regulyatsii protsessov immuniteta (Reproductive Hormones in the Regulation of Immunity), Yekaterinburg: UIF Nauka, 1993.

    Google Scholar 

  4. Ross, G.T., Cargille, C.M., Lipsett, M.B., et al., Pituitary and Gonadal Hormones in Women During Spontaneous and Induced Ovulatory Cycles, Recent Prog. Horm. Res., 1970, vol. 26, p. 1.

    PubMed  CAS  Google Scholar 

  5. Van de Wiele, R.L., Bogumil, R.J., Dyrenfurth, I., et al., Mechanisms Regulating the Menstrual Cycle in Women, Recent Prog. Horm. Res., 1970, vol. 26, p. 63.

    Google Scholar 

  6. Shirshev, S.V., Cellular and Molecular Mechanisms of the Immunomodulating Action of Chorionic Gonadotropin, Usp. Sovr. Biol., 1998, vol. 118, no. 1, p. 69.

    CAS  Google Scholar 

  7. Schufer, A., Pauli, G., Friedmann, W., and Dudenhausen, J.W., Human Choriogonadotropin (hCG) and Placental Lactogen (hPL) Inhibit Interlekin-2 (IL-2) and Increase Interleukin-1-beta (IL-1beta), Interleukin-6 (IL-6) and Tumor Necrosis Factor (TNF-alfa) Expression in Monocyte Cell Cultures, J. Perinat. Med., 1992, vol. 20, no. 3, p. 233.

    Article  Google Scholar 

  8. Magnie, M., Valtora, A., Maretta, A., et al., Effects of Chorionic Gonadotropin (hCG) Therapy on the Immune System, Medicina (Firenze), 1990, vol. 10, no. 2, p. 148.

    Google Scholar 

  9. Nathan, C.F., Secretory Product of Macrophages, J. Clin. Invest., 1987, vol. 79, no. 2, p. 319.

    Article  PubMed  CAS  Google Scholar 

  10. Banchereau, J. and Steinman, R.M., Dendritic Cells and the Control of Immunity, Nature, 1998, vol. 392, p. 245.

    Article  PubMed  CAS  Google Scholar 

  11. Rissoan, M.C., Soumelis, V., Kadowski, N., et al., Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation, Science, 1999, vol. 283, p. 1183.

    Article  PubMed  CAS  Google Scholar 

  12. Abrahams, V.M., Kim, Y.M., Straszewski, S.L., et al., Macrophages and Apoptotic Cell Clearance during Pregnancy, Am. J. Reprod. Immunol., 2004, vol. 51, no. 4, p. 275.

    Article  PubMed  Google Scholar 

  13. Lu, D.L., Peegel, H., Moiser, S.M., and Menon, K.M., Loss of Lutropin/Human Choriogonadotropin Receptor Messenger Ribonucleic Acid during Ligand-Induced Down-Regulation Occurs Posttranscriptionally, Edocrinology, 1993, vol. 132, no. 1, p. 235.

    Article  CAS  Google Scholar 

  14. Adonakis, G., Deshpande, N., Yates, R.W., and Fleming, R., Luteinizing Hormone Increases Estradiol Secretion but Has No Effect on Progesterone Concentrations in the Late Follicular Phase of In vitro Fertilization Cycles in Women Treated with Gonadotropin-Releasing Hormone Agonist and Follicle-Stimulating Hormone, Fertil. Steril., 1998, vol. 69, no. 3, p. 450.

    Article  PubMed  CAS  Google Scholar 

  15. Pertof, H., Johnsson, A., Warmegard, B., and Seljelid, R., Separation of Human Monocytes on Density Gradients of Percoll, J. Immunol. Methods, 1980, vol. 33, no. 3, p. 221.

    Article  Google Scholar 

  16. Wide, L., An Immunological Method for the Assay of Human Chorionic Gonadotropin, Acta Endocrinol. (Kbh), 1962, vol. 41, suppl. 70, p. 1.

    Google Scholar 

  17. Kaplin, V.N., Netraditsionnaya immunologiya infektsii (Nontraditional Immunology of Infection), Perm: Perm. State Med. Akad., 1996.

    Google Scholar 

  18. Wiedemann, A., Linder, S., Grassl, G., et al., Yersinia enterocolitica Invasin Triggers Phagocytosis via Beta 1 Integrins, CDC42Hs and WASp in Macrophages, Cell Microbiol., 2001, vol. 3, no. 10, p. 693.

    Article  PubMed  CAS  Google Scholar 

  19. Morikawa, K., Watabe, H., Araake, M., and Morikawa, S., Modulatory Effect of Antibiotics on Cytokine Production by Human Monocytes In vitro, Antimicrob. Agents Chemother., 1996, vol. 40, no. 6, p. 1366.

    PubMed  CAS  Google Scholar 

  20. Bakuev, M.M., Saidov, M.Z., and Butakov, A.A., Variations in the Myeloperoxidase Secretion in the Chemiluminescent Response of Human Neutrophils to Various Stimulators, Immunologiya, 1991, no. 1, p. 15.

  21. O’Connor, C.M., Gaffney, K., Keane, J., et al., Alpha 1-Proteinase Inhibitor, Elastase Activity, and Lung Disease Severity in Cystic Fibrosis, Am. Rev. Respir, Dis., 1993, vol. 148, no. 6, pt. 1, p. 1665.

    CAS  Google Scholar 

  22. Shirshev, S.V., Mekhanizmy immunoendokrinnogo kontrolya protsessov reproduktsii (Mechanisms of the Immunoendocrine Control of Reproductive Processes), Yekateringurg: UrO RAN, 2002, vol. 2, p. 557.

    Google Scholar 

  23. Roberts, R.M., A Novel Group of Interferons Associated with the Early Ovine and Bovine Embryo, J. Interferon Res., 1989, vol. 9, no. 4, p. 373.

    PubMed  CAS  Google Scholar 

  24. Strikantan, L., Shartiva, D., Kleiman, N.K., et al., Differential Effect of Alpha and Gamma Interferons on Angiogenesis in Human Endothelial Cells in Culture, J. Cell. Biol., 1990, vol. 111, pt. 2, p. 147.

    Google Scholar 

  25. Hyka, N., Dayer, J.M., Modoux, C., et al., Apolipoprotein A-I Inhibits the Production of Interleukin-1-Beta and Tumor Necrosis Factor-Alpha by Blocking Contact-Mediated Activation of Monocytes by T Lymphocytes, Blood, 2001, vol. 97, no. 8, p. 2381.

    Article  PubMed  CAS  Google Scholar 

  26. Zheng, L., Nukuna, B., Brennan, M.L., et al., Apolipoprotein A-I is a Selective Target for Myeloperoxidase-Catalyzed Oxidation and Functional Impairment in Subjects with Cardiovascular Disease, J. Clin. Invest., 2004, vol. 114, no. 4, p. 529.

    Article  PubMed  CAS  Google Scholar 

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Original Russian Text © S.V. Shirshev, S.A. Zamorina, O.A. Krapivina, 2006, published in Fiziologiya Cheloveka, 2006, Vol. 32, No. 4, pp. 102–109.

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Shirshev, S.V., Zamorina, S.A. & Krapivina, O.A. Effects of chorionic gonadotropin on peripheral monocytes vary with the phases of the menstrual cycle. Hum Physiol 32, 461–467 (2006). https://doi.org/10.1134/S036211970604013X

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