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Indicators of activation of plasminogen and growth factors in nevus and skin melanoma

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Abstract

Skin melanoma is believed to arise from the malignant development of congenital or acquired pigmented nevi under the action of various causative agents. A study of samples of skin melanoma tissues, as well as pigmented nevus tissues that were obtained from patients of both sexes, was carried out using enzymelinked immunosorbent assay. The study included a comparative analysis of activities of plasmin and plasminogen, as well as the activities and concentrations of urokinase type plasminogen activator, tissue-type plasminogen activator, and an inhibitor of plasminogen activator, as well as the levels of a number of growth factors, including vascular endothelial growth factor and its receptor, epidermal growth factor and its receptor, transforming growth factor, fibroblast growth factor, and finally insulin-like growth factors 1 and 2. The data underpin the possibility of malignant transformation of skin nevi and indicate provisional mechanisms of tumorigenesis. These results are useful for the development of preventive and risk evaluation methods for neoplastic transformation.

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Abbreviations

uPA:

urokinase-type plasminogen activator

tPA:

tissue-type plasminogen activator

PAI-1:

plasminogen activator inhibitor

VEGF:

vascular endothelial growth factor

VEGF-R:

receptor of vascular endothelial growth factor

EGF:

epidermal growth factor

EGF-R:

receptor of epidermal growth factor

β-TGF:

transforming growth factor

FGF:

fibroblast growth factor

IFR-1:

insulin-like growth factor 1

IFR-2:

insulin-like growth factor 2

ELISA:

enzyme-linked immunosorbent assay

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Authors and Affiliations

  1. Rostov Scientific Research Institute of Oncology, Rostov-na-Donu, 344037, Russia

    E. M. Frantsiyants, E. F. Komarova, V. V. Pozdnyakova, L. Ya. Rozenko, Yu. A. Pogorelova, N. D. Cheryarina & O. V. Khokhlova

Authors
  1. E. M. Frantsiyants
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  2. E. F. Komarova
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  3. V. V. Pozdnyakova
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  4. L. Ya. Rozenko
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  5. Yu. A. Pogorelova
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  6. N. D. Cheryarina
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  7. O. V. Khokhlova
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Correspondence to E. M. Frantsiyants.

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Original Russian Text © E.M. Frantsiyants, E.F. Komarova, V.V. Pozdnyakova, L.Ya. Rozenko, Yu.A. Pogorelova, N.D. Cheryarina, O.V. Khokhlova, 2014, published in Molekulyarnaya Biologiya, 2014, Vol. 48, No. 3, pp. 518–522.

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Frantsiyants, E.M., Komarova, E.F., Pozdnyakova, V.V. et al. Indicators of activation of plasminogen and growth factors in nevus and skin melanoma. Mol Biol 48, 448–451 (2014). https://doi.org/10.1134/S0026893314030030

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  • DOI: https://doi.org/10.1134/S0026893314030030

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