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Prenylation: From bacteria to eukaryotes

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Abstract

For their protection from host cell immune defense, intracellular pathogens of eukaryotic cells developed a variety of mechanisms, including secretion systems III and IV which can inject bacterial effectors directly into eukaryotic cells. These effectors may function inside the host cell and may be posttranslationally modified by host cell machinery. Recently, prenylation was added to the list of possible posttranslational modifications of bacterial proteins. In this work we describe the current state of the knowledge about the prenylation of eukaryotic and prokaryotic proteins and prenylation inhibitors. The bioinformatics analyses suggest the possibility of prenylation for a number of Francisella genus proteins.

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Abbreviations

DPPS:

decaprenyl pyrophosphate syntase

FGPPS:

farnesyl pyrophosphate synthase

FPP:

farnesyl pyrophosphate

FT:

farnesyltransferase

FTI:

farnesyltransferase inhibitors

GGPPS:

geranylgeranyl pyrophosphate synthase

GGT1:

geranylgeranyltransferase type I

GGT2:

geranylgeranyltransferase type II

GPP:

geranyl pyrophosphate

HepPPS:

heptaprenyl pyrophosphate synthase

HMG-CoA:

3-hydroxy-3-methylglutaryl-coenzyme A

ICMT:

isoprenyl-cysteine carboxyl methyltransferase

IPP:

isopentenyl pyrophosphate)

IPPS:

(isoprenyl pyrophosphate synthases)

MVA:

mevalonate

MVAP:

5-phosphomevalonate

OPPS:

octaprenyl pyrophosphate synthase

RCE1:

Ras-converting enzyme 1

SCV:

Salmonella-containing vacuole)

SPPS:

solanesyl pyrophosphate synthase)

UPP:

undecaprenyl pyrophosphate synthase

ER:

endoplasmic reticulum

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Authors and Affiliations

  1. School of Systems Biology, David King Hall, George Mason University, Fairfax, VA, 22030, USA

    E. S. Marakasova, M. Amaya, M. L. van Hoek & A. V. Baranova

  2. Metchnikov Research Institute for Vaccines and Serum, Russian Academy of Medical Sciences, Moscow, 105064, Russia

    E. S. Marakasova & N. K. Akhmatova

  3. Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, 138671, Singapore

    B. Eisenhaber & F. Eisenhaber

  4. Department of Biological Sciences, National University of Singapore, Singapore, 117597, Singapore

    B. Eisenhaber

  5. School of Computer Engineering, Nanyang Technological University, Singapore, 637553, Singapore

    B. Eisenhaber

  6. Research Centre for Medical Genetics, Russian Academy of Medical Sciences, Moscow, 115478, Russia

    A. V. Baranova

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  1. E. S. Marakasova
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  2. N. K. Akhmatova
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  3. M. Amaya
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Original Russian Text © E.S. Marakasova, N.K. Akhmatova, M. Amaya, B. Eisenhaber, F. Eisenhaber, M.L. van Hoek, A.V. Baranova, 2013, published in Molekulyarnaya Biologiya, 2013, Vol. 47, No. 5, pp. 717–730.

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Marakasova, E.S., Akhmatova, N.K., Amaya, M. et al. Prenylation: From bacteria to eukaryotes. Mol Biol 47, 622–633 (2013). https://doi.org/10.1134/S0026893313050130

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