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Linkage and association of proinflammatory cytokines genes IL-6, IFNG and TNF with multiple sclerosis

  • Genomics and Transcriptomics
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Abstract

Proinflammatory cytokines interleukin-6 (IL-6), interferon-γ (IFNg) and tumor necrosis factor (TNF) play an important role in the pathogenesis of multiple sclerosis. Based on the published data concerning the effects of the SNPs G(−308)A of TNF, A(+874)T of IFNG, and G(−174)C of IL-6 on the production of these cytokines, we investigated the relation of these polymorphisms with multiple sclerosis. Linkage and association of alleles of these genes with multiple sclerosis were analyzed by transmission disequilibrium test. In a group of 104 nuclear families of Russian ethnicity, the TNF*(−308)A allele was more frequently transmitted from healthy heterozygous parents to affected children (p = 0.01). Linkage/association of IFNG and IL-6 alleles with multiple sclerosis was not detected. Thus, the data obtained indicate that TNF is involved in susceptibility to multiple sclerosis in Russians.

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Abbreviations

MS:

multiple sclerosis

CNS:

central nervous system

EDTA:

ethylendiaminetetraacetate

IL-6:

(IL-6), interleukin-6 (its gene)

IFNg (IFNG):

interferon-γ (its gene)

SNP:

single nucleotide polymorphism

TDT:

transmission disequilibrium test

TNF (TNF):

tumornecrosis factor (its gene)

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Authors and Affiliations

  1. Russian Cardiological Research and Production Center, Moscow, 121552, Russia

    O. Yu. Makarycheva, E. Yu. Tsareva, M. A. Sudomoina, O. G. Kulakova & O. O. Favorova

  2. N.I. Pirogov Russian State Medical University, Moscow, 117437, Russia

    E. Yu. Tsareva, M. A. Sudomoina, O. G. Kulakova, A. N. Boiko & O. O. Favorova

  3. Science Center for Children Health, Russian Academy of Medical Sciences, Moscow, 119991, Russia

    O. V. Bykova, N. V. Gol’tsova & L. M. Kuzenkova

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  1. O. Yu. Makarycheva
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  2. E. Yu. Tsareva
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  3. M. A. Sudomoina
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  4. O. G. Kulakova
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  5. O. V. Bykova
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  6. N. V. Gol’tsova
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  7. L. M. Kuzenkova
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  8. A. N. Boiko
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  9. O. O. Favorova
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Correspondence to O. O. Favorova.

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Original Russian Text © O.Yu. Makarycheva, E.Yu. Tsareva, M.A. Sudomoina, O.G. Kulakova, O.V. Bykova, N.V. Gol’tsova, L.M. Kuzenkova, A.N. Boiko, O.O. Favorova, 2010, published in Molekulyarnaya Biologiya, 2010, Vol. 44, No. 5, pp. 824–830.

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Makarycheva, O.Y., Tsareva, E.Y., Sudomoina, M.A. et al. Linkage and association of proinflammatory cytokines genes IL-6, IFNG and TNF with multiple sclerosis. Mol Biol 44, 728–733 (2010). https://doi.org/10.1134/S0026893310050079

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