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Association of the polymorphic markers G(−455)A in the FGB gene and C(−1654)T in the PROC gene with hereditary predisposition to unfavourable outcome in patients with history of acute coronary syndrome

  • Genomics and Transcriptomics
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Abstract

Associations of polymorphisms of genes FGB G(−455)A and PROC C(−1654)T with the frequency of poor outcomes in patients with the history of acute coronary syndrome (ACS) were studied in the Russian population. A total of 1145 patients admitted to cardiological hospitals of Moscow, St. Petersburg, Kazan, Chelyabinsk, Perm, Stavropol, and Rostov-on-Don with ischemic heart disease exacerbation were examined. The mean follow-up time was 1.14 ± 0.33 years, and the maximum follow-up time was 3.2 years. The risk of poor outcome did not depend on the carriership of genotypes of the polymorphic G(−455)A marker in the FGB gene. However, the PROC C(−1654)T polymorphism patients with ACS history and allele T of the PROC gene had a poor outcome more often than patients homozygous for allele C. The survival time to the endpoint for carriers of the TT and CT genotypes of the PROC gene was 2.19 ± 0.18 years vs. 2.46 ± 0.16 years for carriers of the CC genotype. On the base of these results it is suggested that hemostasis-related genes play an important role in early failures in patients with ACS history.

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Abbreviations

IHD:

ischemic heart disease

MI:

myocardial infarction

LDL:

low-density lipoproteins

ACS:

acute coronary syndrome

CVD:

cardiovascular diseases

FGB:

gene coding β-chain of fibrinogen

PROC:

gene coding protein C.

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Authors and Affiliations

  1. State Research Center GosNII Genetika, Moscow, 117545, Russia

    Yu. V. Agapkina, A. G. Nikitin, A. N. Brovkin, A. A. Pushkov & V. V. Nosikov

  2. FSI “Educational scientific medical center” of the General management departament of the President of the Russian Federation, Moscow, 121359, Russia

    M. A. Evdokimova, O. Yu. Aseycheva, V. S. Osmolovskaya, L. O. Minushkina, M. S. Kochkina, N. D. Selezneva, E. N. Dankovtseva, O. S. Chumakova, B. A. Sidorenko & D. A. Zateyshchikov

  3. Municipal Hospital no. 17, Moscow, 119620, Russia

    T. N. Baklanova, P. A. Talyzin & N. E. Reznichenko

  4. Administrative Department of the President of the Russian Federation, Clinical Hospital no. 1, Moscow, 107143, Russia

    O. P. Donetskaya

  5. Moscow State University of Medicine and Dentistry, Moscow, 127473, Russia

    S. N. Tereschenko, E. S. Krasil’nikova, N. A. Dzhaiani & E. V. Akatova

  6. Sechenov Moscow Medical Academy, Moscow, 119991, Russia

    M. G. Glezer

  7. Kazan State Medical University, Kazan, 420012, Russia

    A. S. Galyavich & V. B. Zakirova

  8. Vagner Perm State Medical Academy, Perm, 614000, Russia

    N. A. Koziolova & I. V. Timofeeva

  9. Stavropol State Medical Academy, Stavropol, 355014, Russia

    A. V. Yagoda & O. I. Boyeva

  10. Rostov State Medical University, Rostov-on-Don, 344022, Russia

    L. I. Katelnitskaya, E. V. Horolets & S. V. Shlyk

  11. Chelyabinsk State Medical Academy, Chelyabinsk, 454092, Russia

    E. G. Volkova, M. P. Margaryan & I. O. Guz

  12. Saint Petersburg State Mechnikov Medical Academy, St. Petersburg, 195067, Russia

    V. O. Konstantinov & A. N. Timofeyeva

Authors
  1. Yu. V. Agapkina
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  2. A. G. Nikitin
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  3. A. N. Brovkin
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  4. A. A. Pushkov
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  5. M. A. Evdokimova
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  6. O. Yu. Aseycheva
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  7. V. S. Osmolovskaya
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  8. L. O. Minushkina
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  9. M. S. Kochkina
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  10. N. D. Selezneva
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  11. E. N. Dankovtseva
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  12. O. S. Chumakova
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  13. T. N. Baklanova
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  14. P. A. Talyzin
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  15. N. E. Reznichenko
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  16. O. P. Donetskaya
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  17. S. N. Tereschenko
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  18. E. S. Krasil’nikova
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  19. N. A. Dzhaiani
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  20. E. V. Akatova
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  21. M. G. Glezer
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  22. A. S. Galyavich
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  23. V. B. Zakirova
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  24. N. A. Koziolova
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  25. I. V. Timofeeva
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  26. A. V. Yagoda
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  27. O. I. Boyeva
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  28. L. I. Katelnitskaya
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  29. E. V. Horolets
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  30. S. V. Shlyk
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  31. E. G. Volkova
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  32. M. P. Margaryan
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  33. I. O. Guz
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  34. V. O. Konstantinov
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  35. A. N. Timofeyeva
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  36. B. A. Sidorenko
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  37. D. A. Zateyshchikov
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  38. V. V. Nosikov
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Corresponding author

Correspondence to V. V. Nosikov.

Additional information

Original Russian Text © Yu.V. Agapkina, A.G. Nikitin, A.N. Brovkin, A.A. Pushkov, M.A. Evdokimova, O.Yu. Aseycheva, V.S. Osmolovskaya, L.O. Minushkina, M.S. Kochkina, N.D. Selezneva, E.N. Dankovtseva, O.S. Chumakova, T.N. Baklanova, P.A. Talyzin, N.E. Reznichenko, O.P. Donetskaya, S.N. Tereschenko, E.S. Krasil’nikova, N.A. Dzhaiani, E.V. Akatova, M.G. Glezer, A.S. Galyavich, V.B. Zakirova, N.A. Koziolova, I.V. Timofeeva, A.V. Yagoda, O.I. Boyeva, L.I. Katelnitskaya, E.V. Horolets, S.V. Shlyk, E.G. Volkova, M.P. Margaryan, I.O. Guz, V.O. Konstantinov, A.N. Timofeyeva, B.A. Sidorenko, D.A. Zateyshchikov, V.V. Nosikov, 2010, published in Molekulyarnaya Biologiya, 2010, Vol. 44, No. 4, pp. 613–619.

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Agapkina, Y.V., Nikitin, A.G., Brovkin, A.N. et al. Association of the polymorphic markers G(−455)A in the FGB gene and C(−1654)T in the PROC gene with hereditary predisposition to unfavourable outcome in patients with history of acute coronary syndrome. Mol Biol 44, 541–545 (2010). https://doi.org/10.1134/S0026893310040060

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  • DOI: https://doi.org/10.1134/S0026893310040060

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