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XPS study of pharmacological substances mechanochemically immobilized on the surface of alumina

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Abstract

Piroxicam and meloxicam nanocomposites with alumina were synthesized by mechanochemical treatment of medicinal substances mixed with the oxide. X-ray photoelectron spectroscopy demonstrated that interaction of the components during mechanical activation proceeds via binding the amide and sulfate groups in the molecules of medicinal substances with the active sites of alumina surface. XPS studies confirmed the formation of “core-shell” composites with the shell represented by medicinal substances distributed over the support surface.

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Authors and Affiliations

  1. G. K. Boreskov Institute of Catalysis, Siberian Division, Russian Academy of Sciences, Novosibirsk, Russia

    A. I. Nizovskii & A. V. Kalinkin

  2. Institute of Solid State Chemistry and Mechanochemistry, Siberian Division, Russian Academy of Sciences, Novosibirsk, Russia

    T. P. Shakhtshneider, S. A. Myz & E. V. Boldyreva

  3. Scientific-Educational Center “Molecular Design and Environmentally Safe Technologies” at the Novosibirsk State University, Novosibirsk, Russia

    T. P. Shakhtshneider, M. A. Dyakonova, S. A. Myz & E. V. Boldyreva

  4. National Metallurgical Laboratory, Jamshedpur, India

    Rakesh Kumar

Authors
  1. A. I. Nizovskii
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  2. A. V. Kalinkin
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  3. T. P. Shakhtshneider
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  4. M. A. Dyakonova
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  5. S. A. Myz
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  6. E. V. Boldyreva
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  7. Rakesh Kumar
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Corresponding author

Correspondence to A. I. Nizovskii.

Additional information

Original Russian Text Copyright © 2011 by A. I. Nizovskii, A. V. Kalinkin, T. P. Shakhtshneider, M. A. Dyakonova, S. A. Myz, E. V. Boldyreva, and Rakesh Kumar

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Translated from Zhurnal Strukturnoi Khimii, Vol. 52, Supplement, pp. S141–S147, 2011.

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Nizovskii, A.I., Kalinkin, A.V., Shakhtshneider, T.P. et al. XPS study of pharmacological substances mechanochemically immobilized on the surface of alumina. J Struct Chem 52 (Suppl 1), 137–144 (2011). https://doi.org/10.1134/S0022476611070183

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  • DOI: https://doi.org/10.1134/S0022476611070183

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