Abstract
Ultrastructural and stereomorphometric study of the chick embryo right atrium at the 14th day of incubation has shown cardiomyocytes to divide mitotically and to be at different stages of differentiation. The cytoplasm of some muscle cells contains secretory granules that by sizes and morphology can be classified as formed, mature, and dissolved forms. By the 18th day of incubation the majority of cardiomyocytes is already differentiated, and the amount of their secretory granules increases. Under conditions of hypoxia, after three days, in myoendocrine cells there are noted features of accelerated secretion of the peptides that are synthesized earlier and are accumulate in the granules, while after one weak—features of acceleration of their synthesis. It can be concluded that in chick embryos, at least from the 14th day of incubation, the system of the heart natriuretic peptides participates in regulation of hemodynamics and of water—salt balance and responds to hypoxia.
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de Bold, A.J., Borenstein, H.B., Veress, A.T., and Sonnenberg, H., A Rapid and Potent Natriuretic Response to Intravenous Injection of Atrial Myocardial Extract in Rats, Life. Sci., 1981, vol. 28, pp. 89–94.
Cameron, V.A. and Ellmers, L.J., Minireview: Natriuretic Peptides during Development of the Fetal Heart and Circulation, Endocrinology, 2003, vol. 144, no. 6, pp. 2191–2194.
Stephenson, T.J. and Pipkin, F.B., Atrial Natriuretic Factor: the Heart as an Endocrine Organ, Arch. Dis. Child., 1990, vol. 65, pp. 1293–1294.
Walther, T., Schultheiss, H.P., Tschope, C., and Stepan, H., Natriuretic Peptide System in Fetal Heart and Circulation, J. Hypertens., 2002, vol. 20, no. 5, pp. 801–803.
Inoue, K. and Takei, Y., Molecular Evolution of the Natriuretic Peptide System as Revealed by Comparative Genomics, Comp. Biochem. Physiol. Part D: Genomics and Proteomics, 2006, vol. 1, no. 1, pp. 69–76.
Takei, Y., Inoue, K., Trajanovska, S., and Donald, J., B-Type Natriuretic Peptide (BNP), Not ANP, Is the Principal Cardiac Natriuretic Peptide in Vertebrates as Revealed by Comparative Studies, Gen. Comp. Endocrinol., 2011, vol. 171, no. 3, pp. 258–266.
Takle, H., Baeverfjord, G., Helland, S., Kjorsvik, E., and Andersen, O., Hyperthermia Induced Atrial Natriuretic Peptide Expression and Deviant Heart Development in Secretory Granules of Atlantic Salmon Salmo salar Embryos, Gen. Comp. Endocrinol., 2006, vol. 147, no. 2, pp. 118–125.
Krylova, M.I., Chemogranin A: Immunocytochemical Localization in Frog Atrium Cardiomyocytes, Tsitologiya, 2007, vol. 49, no.7, pp. 538–543.
Reinhart, G.A. and Zehr, J.E., Atrial Natriuretic Factor in the Freshwater Turtle Pseudemys scripta: a Partial Characterization, Gen. Comp. Endocrinol., 1994, vol. 96, no. 2, pp. 259–269.
Trajanovska, S., Inoue, K., Takei, Y., and Donald, J.A., Genomic Analyses and Cloning of Novel Chicken Natriuretic Peptide Genes Reveal New Insights into Natriuretic Peptide Evolution, Peptides, 2007, vol. 28, no. 11, pp. 2155–2163.
Trajanovska, S. and Donald, J.A., Molecular Cloning of Natriuretic Peptides from the Heart of Reptiles: Loss of ANP in Diapsid Reptiles and Birds, Gen. Comp. Endocrinol., 2008, vol. 156, no. 2, pp. 339–346.
Orlov, M.V., Biologicheskii control’ v inkubatsii (Biological Control in Incubation), Moscow, 1987.
Fisinin, V.I., Zhuravlev, I.V., and Aidinyan, T.G., Embrional’noe razvitie ptitsy (Embryonic Bird Development), Moscow, 1990.
Avramovitch, N., Hoffman, A., Winaver, J., Haramati, A., and Lewinson, D., Morphometric Analysis of Atrial Natriuretic Peptide-Containing Granules in Atriocytes of Rats with Experimental Congestive Heart Failure, Cell. Tissue Res., 1995, vol. 279, no. 3, pp. 575–583.
Rakhcheeva, M.L., Bugrova, M.L., Mukhina, I.V., and Zhabereva, A.S., Role of Atrial Natriuretic Peptide in Regulation of Arterial Pressure under Unilateral Renal Ischemia in Rats Vestnik Nizhegorod. Univer. im. N.I. Lobachevskogo, 2009, vol. 6, no. 1, pp. 132–136.
Keller, B.B., MacLennan, M.J., Tinney, J.P., and Yoshigi, M., In vivo Assessment of Embryonic Cardiovascular Dimensions and Function in Day-10.5 to 14.5-Mouse Embryos, Circulation Res., 1996, vol. 79, pp. 247–255.
Mifune, H., Suzuki, S., Noda, Y., Mohri, S., and Mochizuki, K., Fine Structure of Atrial Natriuretic Peptide (ANP)-Granules in the Atrial Cardiocytes of the Mouse, Rat and Mongolian Gerbil, Jikken Dobutsu, 1991, vol. 40, no. 2, pp. 183–193.
Ruijtenbeek, K., DeMey, J.G.R., and Blanko, C.E., The Chicken Embryo in Developmental Physiology of the Cardiovascular System: a Traditional Model with New Possibilities, Am. J. Physiol., 2002, vol. 282, pp. R331–R333.
Ruijtenbeek, K., Kessels, L.C.G.A., De-Mey, J.G.R., and Blanko, C.E., Chronic Moderate Hypoxia and Protein Malnutrition Both Induce Growth Retardation, but Have Distinct Effects on Arterial Endothelium-Dependent Reactivity in the Chicken Embryo, Pediatr. Res., 2003, vol. 53, no. 4, pp. 573–579.
Villamor, E., Kessels, C.G., Ruijtenbeek, K., van Suylen, R.J., Belik, J., de Mey, J.G., and Blanco, C.E., Chronic in ovo Hypoxia Decreases Pulmonary Arterial Contractile Reactivity and Induces Biventricular Cardiac Enlargement in the Chicken Embryo, Am. J. Physiol. Regul. Integr. Comp. Physiol., 2004, vol. 287, no. 3, pp. R642–R651.
Möllmann, H., Nef, H.M., Kostin, S., Dragu, A., Maack, C., Weber, M., Troidl, C., Rolf, A., Elsässer, A., Böhm, M., Brantner, R., Hamm, C.W., and Holubarsch, C.J., Ischemia Triggers BNP Expression in the Human Myocardium Independent from Mechanical Stress, Int. J. Cardiol., 2010, vol. 143, no. 3, pp. 289–297.
Goetze, J.P., Biosynthesis of Cardiac Natriuretic Peptides. Results and Problems in Cell Differentiation, Springer-Verlag, 2009.
Maksimov, V.F. and Korostyshevskaya, I.M., Development of Chick Embryo Myocardium at Restriction of External Respiration, Morfologiya, 2009, vol. 135, no. 2, pp. 38–42.
Maksimov, V.F. and Korostyshevskaya, I.M., Development of the Chick Embryo Gas-Transport Systems under Conditions of Restriction of Egg Respiratory Surface, Ross. Fiziol. Zh. im. I.M. Sechenova, 2007, vol. 93, no. 12, pp. 1413–1422.
Korostyshevskaya, I.M. and Maksimov, V.F., How Survives Chick Embryo after Closing the Half of Shell?, Ontogenesis, 2009, vol. 40, no. 2, pp. 48–61.
Bonow, R.O., New Insights into the Cardiac Natriuretic Peptides, Circulation, 1996, vol. 93, pp. 1946–1950.
Goetze, J.P., Kastrup, J., and Rehfeld, J.F. The Paradox of Increased Natriuretic Hormones in Congestive Heart Failure Patients: Does the Endocrine Heart Also Fail in Heart Failure?, Eur. Heart. J., 2003, vol. 24, pp. 1471–1472.
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Original Russian Text © V.F. Maksimov, I.M. Korostyshevskaya, 2012, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2012, Vol. 48, No. 5, pp. 502–508.
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Maksimov, V.F., Korostyshevskaya, I.M. Morphogenesis and reaction to hypoxia of atrial myoendocrine cells in chick embryos (Gallus gallus). J Evol Biochem Phys 49, 251–258 (2013). https://doi.org/10.1134/S0022093013020151
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DOI: https://doi.org/10.1134/S0022093013020151