Abstract
In sagittal cerebellum sections, morphometrical study of cerebellum of mature-born animals—guinea pigs—was performed using Nissl’s procedure. A change of shape and volume of Purkinje cells and their nuclei in the course of the guinea pig postnatal ontogenesis was studied. It has been shown that both the growth process itself and the rate of formation of the definite form of Purkinje cells and of their nuclei in the course of ontogenesis proceeds non-uniformly. The most intensive growth of vertical and horizontal diameters of Purkinje cells and of their nuclei is observed during the 1st and 4th weeks of postnatal life. Especially rapid is an increase of horizontal diameters of Purkinje cells and of their nuclei, which impairs the ovoid-bear-like shape to the cerebellar Purkinje cells of adult guinea pigs.
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References
Ito, M., Historical Review of the Significance of the Cerebellum and the Role of Purkinje Cells in Motor Learning, Ann. N. Y. Acad. Sci., 2002, vol. 978, pp. 273–288.
Kalinchenko, S.G. and Motavkin, P.A., Kora mozzhechka (The Cerebellar Cortex), Moscow, 2005.
Svenson, P., Mozzhechkovye puti i mechanizmy klassicheskogo uslovnogo refleksa (Cerebellar Pathways and Mechanisms of Classical Conditioning), St. Petersburg, 2005.
Woodruf-Pak, D.S., Vogel, R.W., 3rd, Ewers, M., Coffey, J., Boyko, L.B., and Lemieus, S.K., MRI-Assessed Volume of Cerebellum Correlates with Associative Learning, Neurobiol. Learn. Mem., 2001, vol. 76, pp. 342–357.
Oleinik, T.L. and Grigoryan, R.A., Morphometric Study of Development of Cerebellar Purkinje Cells in Rat Postnatal Ontogenesis, Zh. Evol. Biokhim. Fiziol., 1998, vol. 34, pp. 480–484.
Oleinik, T.L. and Grigoryan, R.A., Morphometric Parameters of the Course of Maturation of Cerebellar Purkinje Cells in Kittens, Sb. statei, posv. pamyati chl-korr. RAN, akad. NAN RA V.V. Fanardzhana (Abstr. of Papers Dedic. to Memory of Corresp. Memb. of RAN, Academician of NAN RA V.V. Fanardzhyan), St. Petersburg, 2005, pp. 79–89.
Harreveld, A. and Shade, J.P., Nerve Cell Destruction by Asphyxiation of the Spinal Cord, J. Comp. Neurol., 1962, vol. 21, pp. 410–423.
Andersen, P. and Eccles, J.C., Locating and Identifying Postsynaptic Inhibitory Synapses by the Correlation of Physiological and Histochemical Data, Abstr. Symp. Biol. Hung. Modern Trends in Neuromorphol., 1965, vol. 5, pp. 219–249.
Antonova, A.M., Structural Complexes of Cerebellar Cortex and their Functional Peculiarities in the Comparative-Anatomic Line of Mammals, Strukturnaya i funktsional’naya organizatsiya mozzhechka (Structural and Functional Organization of Cerebellum), Leningrad, 1971, pp. 4–10.
Grigoryan, R.A., Prigarina, E.I., Oleinik, T.L., and Karelina, T.V., Functional Role of Cerebellar Purkinje Cells in Ontogenesis of Postural-Motor Reactions in Mature-and Immature-Born Animals, Zh. Evol. Biokhim. Fiziol., 2003, vol. 39, pp. 559–567.
Dow, R.S. and Moruzzi, G., The Physiology and Pathology of the Cerebellum, Minneapolis: Univ. Minnesota, 1958.
Altman, J., Postnatal Development of the Cerebellar Cortex in the Rat. I. The External Germinal Layer and the Transitional Molecular Layer, J. Comp. Neurol., 1972, vol. 145, pp. 353–397.
Tarasova, E.I. and Grigoryan, R.A., Some Electrophysiological Parameters of Maturation of Cerebellar Purkinje Cells in Ontogenesis, Sovremennye predstavleniya o funktsiyakh mozzhechka (Modern Concepts about Cerebellar Function), Yerevan, 1984, pp. 65–76.
Grigoryan, R.A. and Tarasova, E.I., Maturation of Activity of Guinea Pig Cerebellar Purkinje Cells in Ontogenesis, Neironnye mekhanizmy interotseptivnoi deyatel’nosti mozzhechka (Neuronal Mechanisms of the Cerebellum Interoceptive Activity), Yerevan, 1979, pp. 66–72.
Addison, W.H.F., The Development of the Purkinje Cells and the Cortical Layers in the Cerebellum of the Albino Rat, J. Comp. Neurol., 1911, vol. 21, pp. 459–490.
Ito, M., The Cerebellum and Neural Control, NY: Raven, 1984.
Altman, J. and Das, G.D., Postnatal Neurogenesis in the Guinea Pig, Nature, 1967, vol. 214, pp. 1098–1101.
Dacey, M.L. and Wallace, R.B., Postnatal Neurogenesis in the Feline Cerebellum: A Structural Functional Investigation, Acta Neurobiol. Exp., 1974, vol. 34, pp. 253–263.
Eccles, J., Ito, M., and Szentágotai, J., The Cerebellum as a Neuronal Machine, New York; Heidelberg: Springer, 1967.
Llinas, R. and Simpson, L.J., Cerebellar Control of Movement, Handbook of Behavior. Neurobiology, Llinas, R., Ed., New York: Univ. Med. Center, 1981, vol. 5, pp. 231–302.
Bloedel, J. and Courville, J., A Review of Cerebellar Afferent Systems, Handbook of Physiology, Brooks, V.B., Ed., Baltimore, 1981, vol. 2, pp. 795–830.
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Original Russian Text © T. L. Oleinik, R. A. Grigoryan, 2008, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2008, Vol. 44, No. 1, pp. 94–99.
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Oleinik, T.L., Grigoryan, R.A. Postnatal development of the shape of cerebellar Purkinje cells in guinea pig ontogenesis. J Evol Biochem Phys 44, 109–115 (2008). https://doi.org/10.1134/S0022093008010131
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DOI: https://doi.org/10.1134/S0022093008010131