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The Influence of Hypothermia on Purinergic Synaptic Modulation in the Rat Diaphragm

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Abstract

The pre- and postsynaptic effects of ATP on thermal sensibility in the diaphragm of the rat have been studied. It has been found that reduction in the bath temperatute from 37 to 22°С provokes a decrease in contractile force of diaphragm caused both by electrical stimulation and carbachol. At 37°C adding ATP to the incubation medium increases contractive activity of the diaphragm caused both by electrical stimulation and carbachol. These effects of ATP persist at lower temperatures, but are more prominent in carbachol-induced contractions. It is assumed that the thermosensitive component of purine modulation is located mostly postsynaptically in the diaphragm of the rat.

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Authors and Affiliations

  1. Kazan State Medical University, 420012, Kazan, Russia

    A. E. Khairullin, A. U. Ziganshin & S. N. Grishin

Authors
  1. A. E. Khairullin
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  2. A. U. Ziganshin
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  3. S. N. Grishin
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Correspondence to A. E. Khairullin.

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Conflict of interests. The authors declare that they have no conflicts of interest.Statement on the welfare of humans or animals. This article does not contain any studies involving animals performed by any of the authors.

FUNDINGPublication was carried out partly with the financial support of the Russian Foundation for Basic Research and the Government of the Republic of Tatarstan within the framework of the scientific project no. 18-44-160009.

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Translated by A. Deryabina

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Khairullin, A.E., Ziganshin, A.U. & Grishin, S.N. The Influence of Hypothermia on Purinergic Synaptic Modulation in the Rat Diaphragm. BIOPHYSICS 65, 858–862 (2020). https://doi.org/10.1134/S0006350920050085

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