Abstract
The protein-synthesizing system of hippocampal (CA1, CA3) and sensorimotor cortex neurons is damaged less and recovers much quicker in rats exposed to 8 Gy of γ-radiation under hypoxia/hypercapnia (body temperature 16–18°C) than under usual conditions, as evidenced by microfluorimetry and electron microscopy. The radioprotective effect does not cover the membrane structures (endoplasmic reticulum and Golgi complex), and their restoration is not so prompt.
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R. Ya. Gordon, D. A. Ignat’ev, E. V. Mel’nikova, et al., Biofizika 51, 316 (2006).
A. A. Manina, Radiation Damage and Recovery Processes in the Central Nervous System (Meditsina, Leningrad, 1964) [in Russian].
A. E. Ivanov, N. N. Kurshakova, and V. V. Shikhodyrov, Pathoanatomy of Radiation Sickness (Meditsina, Moscow, 1981) [in Russian].
D. A. Ignat’ev, R. Ya. Gordon, V. V. Vorob’ev, and V. V. Rogachevskii, Biofizika 50, 140 (2005).
S. Fischer, et al, Mol. Brain Res. 74, 135 (1999).
Z. Zhang, R. A. Sobel, D. Cheng, et al., Mol. Brain Res. 95, 75 (2001).
K. L. Drew, M. E. Rice, T. B. Kuhn and M. A. Smith, Free Radic. Biol. Med. 31, 563 (2001).
K. B. Storey and J. M. Storey, Biol. Rev. 79, 207 (2004).
R. Ya. Gordon, D. A. Ignat’ev, V. V. Rogachevskii, et al., Zh. Evol. Biokhim. Fiziol. 42, 237 (2006).
D. A. Ignat’ev, G. S. Sukhova, and V. P. Sukhov, Zh. Obshch, Biol. 62, 66 (2001).
J. Giaja, Biol. Med. 42, 545 (1953).
M. N. Timofeev, Artificial Hypobiosis (Moscow, 1983).
R. Ya. Gordon, L. S. Bocharova, I. I. Kruman, et al., Cytometry 29, 215 (1997).
V. N. Karnaukhov, V. A. Yashin, A. R. Kazantsev, et al., Tsitologiya 29, 113 (1987).
V. N. Karnaukhov, Spectral Analysis of Cells in the Monitoring of the Environment (Nauka, Moscow, 2001) [in Russian].
M. P. Matson and S. B. Kater, Brain Res. 490, 110 (1989).
M. Benderitter, L. Vincent-Genod, J. P. Pouget and P. Voisin, Radiat. Res. 159, 471 (2003).
Ph. Tofilon and J. R. Fike, Radiat. Res. 153, 357 (2000).
A. F. Protas, Radiats. Biol. Radioekol. 37, 320 (1997).
S-M. Chin, N. L. Oleinick, L. R. Friedman, and P. J. Stambrook, Biochim. Biophys. Acta 699, 15 (1982).
J. M. Klorak, D. McClain, S. L. Snyder, et al., Radiat. Res. 118, 330 (1989).
I. B. Zbarskii and S. N. Kuz’mina, Skeletal Structures of the Cell Nucleus (Nauka, Moscow, 1991) [in Russian].
K. Elmroch, L. J. Erkell and R. Hultborn, Radiat. Res. 152, 137 (1999).
R. Ya. Gordon, E. G. Novoselova, N. L. Kruglova, et al., Biofizika 46, 676 (2001).
K. Roy, S. Kodama, K. Susuki, et al., Radiat. Res. 154, 659 (2000).
J. K. Chen, L. J. Hu, J. Wong, et al., Radiat. Res. 163, 644 (2005).
K. U. Frerichs, C. B. Smith, M. Brenner, et al., Proc. Natl. Acad. Sci. USA 95, 14511 (1998).
D. A. Ignat’ev, V. I. Zagnoiko, G. S. Sukhova, et al., Zh. Obshch, Biol. 56, 450 (1995).
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Original Russian Text © R.Ya. Gordon, D.A. Ignat’ev, E.V. Mel’nikova, V.V. Rogachevskii, I.V. Kraev, S.S. Khutsyan, 2007, published in Biofizika, 2007, Vol. 52, No. 3, pp. 565–571.
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Gordon, R.Y., Ignat’ev, D.A., Mel’nikova, E.V. et al. Protective effect of hypothermia on brain neurons in rats exposed to ionizing radiation. BIOPHYSICS 52, 344–349 (2007). https://doi.org/10.1134/S0006350907030165
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DOI: https://doi.org/10.1134/S0006350907030165