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Electroanalysis of Biomolecules: Rational Selection of Sensor Construction

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Abstract

Methods of electrochemical analysis of biological objects based on the reaction of electro-oxidation/electro-reduction of molecules are presented. Polymer nanocomposite materials that modify electrodes to increase sensitivity of electrochemical events on the surface of electrodes are described. Examples of applications electrochemical biosensors constructed with nanocomposite material for detection of biological molecules are presented, advantages and drawbacks of different applications are discussed.

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Abbreviations

DPV:

differential pulse voltammetry

dsDNA:

double-stranded DNA

LOD:

limit of detection

Mb:

myoglobin

MWCNT:

multi-walled carbon nanotubes

PILs:

poly(ionic liquid)s

SPE:

screen-printed graphite electrode

Trp:

tryptophan

Tyr:

tyrosine

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Funding

The work was done in the framework of the Russian Federation fundamental research program for the long-term period for 2021-2030. The modification of electrode surfaces by polymer materials was financially supported by the Russian Science Foundation (project no. 18-44-04011).

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Authors and Affiliations

  1. Laboratory of Bioelectrochemistry, Orekhovich Research Institute of Biomedical Chemistry, 119992, Moscow, Russia

    Victoria V. Shumyantseva, Lubov E. Agafonova, Tatiana V. Bulko, Alexey V. Kuzikov, Rami A. Masamrekh & Larisa V. Sigolaeva

  2. Department of Biochemistry, Pirogov Russian National Research Medical University, 117997, Moscow, Russia

    Victoria V. Shumyantseva, Alexey V. Kuzikov & Rami A. Masamrekh

  3. Department of Materials and Environmental Chemistry, Stockholm University, 10691, Stockholm, Sweden

    Jiayin Yuan

  4. Faculty of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia

    Dmitry V. Pergushov & Larisa V. Sigolaeva

Authors
  1. Victoria V. Shumyantseva
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  2. Lubov E. Agafonova
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  3. Tatiana V. Bulko
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  7. Dmitry V. Pergushov
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  8. Larisa V. Sigolaeva
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Correspondence to Victoria V. Shumyantseva.

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The authors declare no conflict of interest in financial or any other sphere. This article does not contain any studies with human participants or animals performed by any of the authors.

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Shumyantseva, V.V., Agafonova, L.E., Bulko, T.V. et al. Electroanalysis of Biomolecules: Rational Selection of Sensor Construction. Biochemistry Moscow 86 (Suppl 1), S140–S151 (2021). https://doi.org/10.1134/S0006297921140108

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