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Role of atypical protein kinases in maintenance of long-term memory and synaptic plasticity

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Abstract

Investigation of biochemical mechanisms underlying the long-term storage of information in nervous system is one of main problems of modern neurobiology. As a molecular basis of long-term memory, long-term changes in kinase activities, increase in the level and changes in the subunit composition of receptors in synaptic membranes, local activity of prion-like proteins, and epigenetic modifications of chromatin have been proposed. Perhaps a combination of all or of some of these factors underlies the storage of long-term memory in the brain. Many recent studies have shown an exclusively important role of atypical protein kinases (PKCζ, PKMζ, and PKCι/λ) in processes of learning, consolidation and maintenance of memory. The present review is devoted to consideration of mechanisms of transcriptional and translational control of atypical protein kinases and their roles in induction and maintenance of long-term synaptic plasticity and memory in vertebrates and invertebrates.

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Abbreviations

AMPA:

α-amino-3-hydroxy-5-methyl-4-isoxazolpropionic acid receptor

aPKC:

atypical protein kinase C

CaMKII:

Ca2+/calmodulin-dependent protein kinase II

cAMP:

cyclic adenosine monophosphate

CBP:

CREB-binding protein

CRE:

cAMP response-element

CREB:

a protein binding cAMP-sensitive element (CRE-binding protein)

DAG:

diacylglycerol

DNMT:

DNA methyltransferase

DTEs:

dendritic targeting elements

E-LTP/L-LTP:

early/late longterm potentiation

ERK:

extracellular signal-regulated kinase

GluA:

subunit of glutamate receptor AMPA

GluA1AMPA/GluA2-AMPA:

glutamate AMPA-receptor containing GluA1/GluA2 subunit

HDAC:

histone deacetylase

LTP:

longterm potentiation

mTOR:

mammalian target of rapamycin

PICK1:

protein interacting with C kinase

PI3K:

phosphoinositide-3-kinase

PIN1:

peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

PKA:

protein kinase A

PKC:

protein kinase C

PKCλ:

protein kinase Cλ

PKMζ:

protein kinase Mζ

PS:

phosphatidylserine

shRNA:

short hairpin RNA

TSA:

trichostatin A

uORF:

upstream open reading frame

UTRs:

untranslated regions

ZIP:

Zeta Inhibitory Peptide

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Authors and Affiliations

  1. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485, Moscow, Russia

    A. A. Borodinova, A. B. Zuzina & P. M. Balaban

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  1. A. A. Borodinova
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Original Russian Text © A. A. Borodinova, A. B. Zuzina, P. M. Balaban, 2017, published in Biokhimiya, 2017, Vol. 82, No. 3, pp. 372-388.

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Borodinova, A.A., Zuzina, A.B. & Balaban, P.M. Role of atypical protein kinases in maintenance of long-term memory and synaptic plasticity. Biochemistry Moscow 82, 243–256 (2017). https://doi.org/10.1134/S0006297917030026

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