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Structure, functions, and biosynthesis of glycoconjugates of Leishmania spp. cell surface

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Abstract

Cell surface of leishmaniasis causal agent, a parasitic member of Protozoa of Leishmania genus, is covered by thick glycocalix consisting of various phosphatidylinositol-anchored molecules. This review deals with the structure and biosynthesis of the main phosphoglycans and glycoproteins of Leishmania cell surface, many of which incorporate the rare natural D-arabinopyranose, and the problem concerning the involvement of these molecules in support of Leishmania survival during their intricate life cycle is discussed.

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Abbreviations

D-Ara:

D-arabinose

Gal:

D-galactose

GIPL:

glycosylinositol phospholipids

GlcN:

glucosamine

GPI:

glycosylphosphatidylinositol

Man:

D-mannose (monosaccharides are in pyranose form unless otherwise stated)

PI:

phosphatidylinositol

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  1. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117997, Moscow, Russia

    N. M. Novozhilova & N. V. Bovin

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  1. N. M. Novozhilova
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  2. N. V. Bovin
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Correspondence to N. M. Novozhilova.

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Original Russian Text © N. M. Novozhilova, N. V. Bovin, 2010, published in Biokhimiya, 2010, Vol. 75, No. 6, pp. 770–780.

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Novozhilova, N.M., Bovin, N.V. Structure, functions, and biosynthesis of glycoconjugates of Leishmania spp. cell surface. Biochemistry Moscow 75, 686–694 (2010). https://doi.org/10.1134/S0006297910060027

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