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Thermodynamic study of interaction of TSPP, CoTsPc, and FeTsPc with calf thymus DNA

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Abstract

The interaction of two water soluble phthalocyanines, cobalt(II) 4,4′,4″,4‴-tetrasulfo-phthalocyanine (CoTsPc) and iron(II) 4,4′,4″,4‴-tetrasulfo-phthalocyanine (FeTsPc), and one water soluble porphyrin, tetra sodium mesotetrakis(p-sulfophenyl)porphyrin (TSPP), with calf thymus DNA has been studied by UV-Vis spectroscopy at five different temperatures (20, 25, 30, 35, and 40°C). The optical absorption spectra of these materials were analyzed to obtain binding constants and stoichiometries using SQUAD software. The results show that the best fitting corresponds to a 1: 1 complex model between a base pair of DNA and these materials. All of the studied porphyrin and phthalocyanines showed strong electrolyte effect, and increasing NaCl concentration induced self-aggregation of these materials.

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Abbreviations

CoTsPc:

cobalt(II) 4,4′,4″,4‴-tetrasulfo-phtha-locyanine

FeTsPc:

iron(II) 4,4′,4″,4‴-tetrasulfo-phthalocyanine

TSPP:

tetra sodium meso-tetrakis(p-sulfophenyl)porphyrin

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Authors and Affiliations

  1. Science and Research Campus, Islamic Azad University, P.O. Box 14515-775, Tehran, Iran

    M. Monajjemi, H. Aghaie & F. Naderi

  2. Shahriyar-Shahr e Ghods Branch, Islamic Azad University, Tehran, Iran

    F. Naderi

Authors
  1. M. Monajjemi
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  2. H. Aghaie
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  3. F. Naderi
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Corresponding author

Correspondence to M. Monajjemi.

Additional information

Published in Russian in Biokhimiya, 2007, Vol. 72, No. 6, pp. 799–804.

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Monajjemi, M., Aghaie, H. & Naderi, F. Thermodynamic study of interaction of TSPP, CoTsPc, and FeTsPc with calf thymus DNA. Biochemistry Moscow 72, 652–657 (2007). https://doi.org/10.1134/S0006297907060089

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  • DOI: https://doi.org/10.1134/S0006297907060089

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