Abstract
The review presents the current classification of antimicrobial peptides (AMP), which are the main component of innate immunity. The mechanism of their action and the molecular basis of the formation of resistance towards these peptides are described. Data on the use of AMP for the treatment of various infectious diseases, as well as the state of the art in genetic therapy using AMP, are given.
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Abbreviations
- AMPs:
-
antimicrobial peptides
- cAMPs:
-
cationic AMPs
- SIC:
-
complement inhibitor
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Original Russian Text © V.N. Lazarev, V.M. Govorun, 2010, published in Biotekhnologiya, 2010, No. 3, pp. 11–25.
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Lazarev, V.N., Govorun, V.M. Antimicrobial peptides and their use in medicine. Appl Biochem Microbiol 46, 803–814 (2010). https://doi.org/10.1134/S0003683810090012
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DOI: https://doi.org/10.1134/S0003683810090012