Original paper
Differential effects of hGH and IGF-I on body proportions
Laron, Zvi; Silbergeld, Aviva; Kauli, Rivka
Anthropologischer Anzeiger Volume 69 No. 3 (2012), p. 255 - 259
published: Jul 1, 2012
DOI: 10.1127/0003-5548/2012/0208
ArtNo. ESP140006903001, Price: 29.00 €
Abstract
The differential growth effects of hGH and IGF-I on the upper/lower (U/L) body segment in relation to height (Ht) were analyzed in 15 patients with isolated Growth hormone deficiency (IGHD,:7M, 8F) mean age 5.0 ± 3.2 (SD) years treated with hGH; 21 patients with multiple pituitary hormone deficiency including growth hormone (MPHD: 14M, 7F) aged 10.0 ± 3.8, treated with hGH; 9 patients with Laron Syndrome (LS) (4M,5F) aged 6.9 ± 5.6 years treated with IGF-I; 9 boys with intrauterine growth retardation (IUGR) aged 6.3 ± 1.25 years treated by hGH; and 22 boys with idiopathic short stature (ISS) aged 8.0 ± 1.55 years treated by hGH. The dose of hGH was 33 μg/kg/day, that of IGF-I 180-200 μg/kg/day. Results: the U/L body segment ratio in IGHD patients decreased from 2.3 ± 0.7 to 1.1 ± 0.7 (p < 0.001), and the ht sds increased from -4.9 ± 1.3 to -2.3 ± 1 (p < 0.001) following treatment. in mphd patients the u/l body segment decreased from 1.1 ± 1.1 to -0.6 ± 1.0 (p < 0.001), and the ht sds increased from -3.3 ± 1.4 to -2.5 ± 1.0 (p < 0.009). in the ls group the u/l body segment ratio did not change with igf-i treatment but ht improved from -6.1 ± 1.3 to -4.6 ± 1.2 (p < 0.001), the differential growth response of the children with iugr and with iss resembled that of the children with ls. Conclusions: hGH and IGF-I act differentially on the spine and limbs.